Mouse Anti-CDK5 Recombinant Antibody (VS3-FY2663)
CAT#: VS3-FY2663
The anti-CDK5 antibody is a mouse recombinant monoclonal antibody that has been specifically designed to target human CDK5 protein. It cross-reacts with mouse, rat, monkey. This monoclonal antibody is potential for conducting research on disease research of Lissencephaly 7, with cerebellar hypoplasia (LIS7).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/64535/1202_C5_1_selected.jpg
Normal Tissue
Figure 2 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25% Sertoli cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8909/22984_A_6_6.jpg
Normal Tissue
Figure 3 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8909/22984_A_8_8.jpg
Normal Tissue
Figure 4 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8909/22984_B_8_5.jpg
Normal Tissue
Figure 5 Caudate
Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8909/22984_B_9_7.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8909/22984_A_7_3.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164885-CDK5
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Cyclin dependent kinase 5 of human, mouse, rat and monkey origins
- Species Reactivity
- Human, Mouse, Rat, Monkey
- Applications
- WB, ICC
- Conjugate
- Unconjugated, FITC
- Related Disease
- Lissencephaly 7, with cerebellar hypoplasia (LIS7)
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunocytochemistry: 1/50-1/200
Target
- Alternative Names
- Cyclin Dependent Kinase 5; Serine/Threonine-Protein Kinase PSSALRE; Tau Protein Kinase II Catalytic Subunit; Cell Division Protein Kinase 5; TPKII Catalytic Subunit; Cyclin-Dependent-Like Kinase 5; Protein Kinase CDK5 Splicing
- Gene ID
- 1020
- UniProt ID
- Q00535
- Cellular Localization
- Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus, Synapse
- Post Translation Modifications
- Phosphorylation on Tyr-15 by ABL1 and FYN, and on Ser-159 by casein kinase 1 promotes kinase activity. By contrast, phosphorylation at Thr-14 inhibits activity. Phosphorylation at Ser-159 is essential for maximal catalytic activity.
- Protein Refseq
- NP_004926.1; NP_001157882.1
- Function
- Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "CDK5"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1843z | Mouse Anti-CDK5 Recombinant Antibody (clone 19G5) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG1 |
| MOB-0162CT | Recombinant Mouse anti-Human CDK5 Monoclonal antibody (5F5) | ELISA, FC, ICC, IF, IHC-P, WB | |
| MRO-0342-CN | Rabbit Anti-CDK5 Recombinant Antibody (clone CBACN-140) | WB, IHC, IP, FC | Rabbit IgG |
| ZG-0406F | Mouse Anti-CDK5 Recombinant Antibody (ZG-0406F) | WB, IF | Mouse IgG |
| ZG-0407F | Mouse Anti-CDK5 Recombinant Antibody (ZG-0407F) | WB, ICC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0631 | Hi-Affi™ Rabbit Anti-CDK5 Recombinant Antibody (clone DS631AB) | IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY118 | Mouse Anti-NHP CDK5 Recombinant Antibody (clone 4E4) | WB, IHC, IF, FC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY405 | Anti-CDK5 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1318 | Anti-Human CDK5 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC199 | CytoStream™ Rabbit Anti-CDK5 Recombinant Antibody (VS13-YC199) | WB, IHC-P, FC, IP | Rabbit IgG |
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