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    CNN1

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    For Research Use Only. Not For Clinical Use.


    Background

    CNN1 (Calponin 1) is a Protein Coding gene. Diseases associated with CNN1 include Laryngeal Small Cell Carcinoma and Infantile Digital Fibromatosis. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Endothelin Pathways. Gene Ontology (GO) annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is CNN3.
    Protein class

    Cancer-related genes

    Predicted location

    Intracellular

    Single cell type specificity

    Group enriched (Late spermatids, Early spermatids, Peritubular cells, Breast myoepithelial cells, Smooth muscle cells)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Cell line enhanced (BJ, BJ hTERT+, BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, HBF TERT88, K-562, SuSa, U-2 OS)

    Interaction

    Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1.

    Molecular function

    Actin-binding, Calmodulin-binding

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