Afuco™ Anti-Human CNR1 ADCC Recombinant Antibody (RYI-018), ADCC Enhanced
CAT#: AFC-171CL
Anti-CNR1 ADCC Enhanced Antibody (RYI-018) is an ADCC enhanced antibody produced by our Afuco™ platform. This is a first in class functional antagonist of Cannabinoid 1 Receptor (CB1), under preclinical development for metabolic and fibrotic indications, NASH, liver fibrosis, kidney fibrosis, metabolic disease.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line AF22
Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & actin filaments.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42256/1595_A8_2_selected.jpg
Normal Tissue
Figure 2 Low expression in liver
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_7_4_val_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuropil Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_7_3.jpg
Normal Tissue
Figure 5 Testis
Sertoli cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (ASC diff, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000118432-CNR1
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Specifications
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Metabolic Disease
Product Property
- Purity
- >95% as determined by analysis by RP-HPLC
- Storage
- Short term: store at 4°C (over 6 months), long term: -20°C or -80°C.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1492CL | Human Anti-CNR1 Recombinant Antibody (TAB-1492CL) | FC, FuncS | Human IgG |
| TAB-1492CL-S(P) | Human Anti-CNR1 Recombinant Antibody; scFv Fragment (TAB-1492CL-S(P)) | FC, FuncS | Human scFv |
| TAB-1492CL-F(E) | Human Anti-CNR1 Recombinant Antibody; Fab Fragment (TAB-1492CL-F(E)) | FC, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2987LY | Human Anti-CNR1 Recombinant Antibody (HPAB-2987LY) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) IgG |
| HPAB-2988LY | Human Anti-CNR1 Recombinant Antibody (HPAB-2988LY) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) IgG |
| HPAB-2989LY | Human Anti-CNR1 Recombinant Antibody (HPAB-2989LY) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) IgG |
| HPAB-2990LY | Human Anti-CNR1 Recombinant Antibody (HPAB-2990LY) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) IgG |
| HPAB-2991LY | Human Anti-CNR1 Recombinant Antibody (HPAB-2991LY) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2987LY-S(P) | Mouse Anti-CNR1 Recombinant Antibody; scFv Fragment (HPAB-2987LY-S(P)) | ELISA, WB, FC, FuncS | Mouse scFv |
| HPAB-2988LY-S(P) | Mouse Anti-CNR1 Recombinant Antibody; scFv Fragment (HPAB-2988LY-S(P)) | ELISA, WB, FC, FuncS | Mouse scFv |
| HPAB-2989LY-S(P) | Mouse Anti-CNR1 Recombinant Antibody; scFv Fragment (HPAB-2989LY-S(P)) | ELISA, WB, FC, FuncS | Mouse scFv |
| HPAB-2990LY-S(P) | Mouse Anti-CNR1 Recombinant Antibody; scFv Fragment (HPAB-2990LY-S(P)) | ELISA, WB, FC, FuncS | Mouse scFv |
| HPAB-2991LY-S(P) | Mouse Anti-CNR1 Recombinant Antibody; scFv Fragment (HPAB-2991LY-S(P)) | ELISA, WB, FC, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2987LY-F(E) | Human Anti-CNR1 Recombinant Antibody; Fab Fragment (HPAB-2987LY-F(E)) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) Fab |
| HPAB-2988LY-F(E) | Human Anti-CNR1 Recombinant Antibody; Fab Fragment (HPAB-2988LY-F(E)) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) Fab |
| HPAB-2989LY-F(E) | Human Anti-CNR1 Recombinant Antibody; Fab Fragment (HPAB-2989LY-F(E)) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) Fab |
| HPAB-2990LY-F(E) | Human Anti-CNR1 Recombinant Antibody; Fab Fragment (HPAB-2990LY-F(E)) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) Fab |
| HPAB-2991LY-F(E) | Human Anti-CNR1 Recombinant Antibody; Fab Fragment (HPAB-2991LY-F(E)) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY72 | Human Anti-CNR1 scFv-Fc Chimera (VS-0425-FY72) | Inhib, Antagonist | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC244 | Recombinant Anti-CNR1 Vesicular Antibody, EV Displayed (VS-0425-YC244) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1565 | Anti-CNR1 Immunohistochemistry Kit | IHC |
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