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DDX5
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- PE-A*02:01/Human DDX5 (YLLPAIVHI) MHC Tetramer (MHC-LC1932)
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- Class: Class I
- Antigen: DDX5
- Antigen Species: Human
- Peptide: YLLPAIVHI
- Conjugate: PE
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- APC-A*02:01/Human DDX5 (YLLPAIVHI) MHC Tetramer (MHC-LC2359)
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- Class: Class I
- Antigen: DDX5
- Antigen Species: Human
- Peptide: YLLPAIVHI
- Conjugate: APC
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- Human Anti-DDX5 Recombinant Antibody (clone 1G3) (HPAB-0197-CN)
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- Derivation: Human phage display library
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
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- Recombinant Human Anti-DDX5 Soluble TCR (UD4) (KIH) (VS-0622-YF7030)
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- Species Reactivity: Human
- Epitope: YLLPAIVHI
- MHC: HLA-A*02:01
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-F, IHC-P, ICC, IF, IP
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- AbPlus™ Anti-DDX5 Magnetic Beads (VS-0724-YC771) (VS-0724-YC771)
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- Target: DDX5
- Target Species: Human, Mouse
- Application: IP, Protein Purification
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- Rabbit Anti-DDX5 Recombinant Antibody (clone JM52-30) (MRO-0467-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, FC
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- Human Anti-DDX5 Recombinant Soluble TCR (clone UD4) (scTCR-0313YC-S(P))
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- Species Reactivity: Human
- Epitope: YLLPAIVHI
- MHC: HLA-A*02:01
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- Recombinant Human Anti-DDX5 Soluble TCR (UD4) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1614)
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- Species Reactivity: Human
- Epitope: YLLPAIVHI
- MHC: HLA-A*02:01
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- Recombinant Human Anti-DDX5 Soluble TCR (UD4) (C-Cys) (VS-0622-YF4322)
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- Species Reactivity: Human
- Epitope: YLLPAIVHI
- MHC: HLA-A*02:01
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- Human Anti-DDX5 Recombinant Antibody (clone 1G3); Fab Fragment (HPAB-0197-CN-F(E))
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- Derivation: Human phage display library
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Human Anti-DDX5 Recombinant Antibody (clone 1G3); scFv Fragment (HPAB-0197-CN-S(P))
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- Derivation: Human phage display library
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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- Anti-DDX5 Immunohistochemistry Kit (VS-0325-XY648)
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- Species Reactivity: Human, Mouse, Rat
- Target: DDX5
- Application: IHC
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- Anti-Human DDX5 Immunohistochemistry Kit (VS-0525-XY1962)
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- Species Reactivity: Human
- Target: DDX5
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. Members of this family contain nine conserved motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif, important to ATP binding and hydrolysis as well as RNA binding and unwinding activities. Dysregulation of this gene may play a role in cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2017]
Protein class
Cancer-related genes, Enzymes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Identified in the spliceosome C complex. Interacts with RBM4; the interaction occurs in an RNA-independent manner. Interacts with AGO1 and AGO2. Interacts with ESR1, AR, EP300, CREBBP, POLR2A, TP53, RUNX2 and HDAC1. Self-associates. Interacts with DDX17. Interacts with BRDT. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active). Interacts with DHX36; this interaction occurs in a RNA-dependent manner (PubMed:18279852). Interacts with NUPR1 (By similarity). Interacts with ERCC6 (PubMed:26030138). Interacts with DDX3X in the cytoplasm; this interaction may be more efficient when both proteins are unphosphorylated (PubMed:22034099).
Molecular function
Helicase, Hydrolase, RNA-binding
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