APC-A*02:01/Human DDX5 (YLLPAIVHI) MHC Tetramer
CAT#: MHC-LC2359
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human DDX5 of peptide YLLPAIVHI covering 148-156 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20043/278_G2_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & nucleoli.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71154/1949_B4_1_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5868/642_D2_1_selected.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: High Intensity: Strong Quantity:>75% Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Peritubular cells Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: High Intensity: Strong Quantity: 75%-25% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20043/45622_A_4_6.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20043/45622_A_8_8.jpg
Normal Tissue
Figure 6 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Nuclear Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20043/45892_B_8_5.jpg
Normal Tissue
Figure 7 Colon
Endocrine cells Staining: High Intensity: Strong Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Fibroblasts Staining: High Intensity: Strong Goblet cells Staining: High Intensity: Strong Quantity:>75% Mucosal lymphoid cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20043/45622_A_9_3.jpg
Normal Tissue
Figure 8 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20043/45622_A_8_5.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000108654-DDX5
❮
❯
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- DDX5
- Antigen Species
- Human
- Peptide
- YLLPAIVHI
- Range
- 148-156
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. Alternative splicing results in multiple transcript variants.
- Alternative Names
- DDX5; DEAD-box helicase 5; p68; HLR1; G17P1; HUMP68
- Gene ID
- 1655
- UniProt ID
- P17844
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Improves Multicolor Flow Cytometry
Its ability to be used with multiple fluorescent markers enhances our multicolor flow cytometry applications. This compatibility allows for comprehensive assessment of T cell characteristics, vital for our immune profiling efforts.
Reliable and Consistent Results
Providing reproducible performance, the tetramer is essential in longitudinal studies analyzing T cell functions over time, ensuring confidence in our findings related to immune-related disease models.
Q&As
-
What are the recommended storage conditions for this MHC tetramer?
A: Store the tetramer at 4°C. Avoid freeze-thaw cycles to maintain functionality, and aliquot if necessary for long-term storage, ensuring consistent results in future experiments.
-
How does specificity affect the accuracy of this tetramer's applications?
A: The specificity of this tetramer ensures that only T cells responsive to the hDDX5 148-156 peptide are detected, providing accurate insights into immune engagement and potential therapeutics targeting DDX5 in cancer and other diseases.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Datasheet
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See other products for "DDX5"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2288CT | Recombinant Mouse anti-Human DDX5 Monoclonal antibody (70) | WB, Dot | |
| HPAB-0197-CN | Human Anti-DDX5 Recombinant Antibody (clone 1G3) | ELISA | Human IgG |
| MRO-0467-CN | Rabbit Anti-DDX5 Recombinant Antibody (clone JM52-30) | WB, IF, IHC, IP, FC | Rabbit IgG |
| ZG-0634J | Rabbit Anti-DDX5 Recombinant Antibody (clone 2C3) | ELISA, WB, IHC, IF, FC | Rabbit IgG |
| VS3-FY449 | Recombinant Rabbit Anti-DDX5 Antibody (clone R04-2K2) | WB, IHC-F, IHC-P, ICC, IF, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0962 | Hi-Affi™ Rabbit Anti-DDX5 Recombinant Antibody (clone DS962AB) | WB, IHC, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1932 | PE-A*02:01/Human DDX5 (YLLPAIVHI) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0197-CN-S(P) | Human Anti-DDX5 Recombinant Antibody (clone 1G3); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0197-CN-F(E) | Human Anti-DDX5 Recombinant Antibody (clone 1G3); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC771 | AbPlus™ Anti-DDX5 Magnetic Beads (VS-0724-YC771) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY648 | Anti-DDX5 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1962 | Anti-Human DDX5 Immunohistochemistry Kit | IHC |
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