FCER1G

FDA approved drug targets

Membrane

Group enriched (Hofbauer cells, Macrophages, Kupffer cells, Langerhans cells, NK-cells, monocytes, dendritic cells, granulocytes)

Group enriched (non-classical monocyte, intermediate monocyte, plasmacytoid DC, classical monocyte, myeloid DC, basophil, neutrophil, NK-cell)

Group enriched (HEL, HMC-1, THP-1, U-266/84, U-937)

IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide-linked gamma chains. Associates with FCGR1A; forms a functional signaling complex (PubMed:8611682). The signaling subunit of immunoglobulin gamma (IgG) Fc receptor complex. As a homodimer or a heterodimer of CD247 and FCER1G, associates with the ligand binding subunit FCGR3A to form a functional receptor complex (PubMed:28652325) (By similarity). Associated with CLEC6A (By similarity). Interacts with CLEC4E (PubMed:18776906). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CSF2RB and recruits SYK in response to IL3 stimulation; this interaction is direct (By similarity). Interacts with CD300LH; the interaction may be indirect (By similarity). Interacts with CD300LD (By similarity). Interacts with TARM1 (PubMed:26311901).

IgE-binding protein, Receptor