Anti-HER2 Recombinant Antibody Products

Tetramer Products Recombinant Antibody Products Functional Antibody Products Formats

At Creative Biolabs, we use cutting-edge platforms to provide a comprehensive range of premium HER2-targeted recombinant antibodies to clients worldwide. Our mission is to advance research and discovery by providing unparalleled value and exceptional technical support, allowing our clients to achieve their scientific goals with greater efficiency and success.

HER2: A Crucial Target in Cancer Therapy

HER2 is a membrane-bound tyrosine kinase and oncogene that, when activated, delivers strong proliferative and anti-apoptotic signals to the cell. Overexpression and amplification of the HER2 protein have been associated with key pathways involved in the proliferation and survival of tumor cells, notably in breast, ovarian, and gastric cancers. Due to its significant role in cancer, HER2 serves as a vital marker for clinical treatment monitoring and prognosis. Furthermore, it is a crucial target in the development and selection of targeted therapies for cancer treatment.

Anti-HER2 Recombinant Antibody Products

We are dedicated to advancing your research and innovation forward with high-quality anti-HER2 recombinant antibodies at competitive prices and exemplary technical assistance. Explore our selection of anti-HER2 recombinant antibodies in the list below or click the link for more details and to choose the most suitable option for your research needs.

Cat. No.	Product Name	Target Species	Host Species	Applications
TAB-0195CL	Anti-Human HER2 Recombinant Antibody (Anti-HER2-IgGl)	Human	Human antibody	FC, Cyt
TAB-0195CL-S(P)	Anti-Human HER2 Recombinant Antibody scFv Fragment (Anti-HER2-IgGl)	Human	Human antibody	FC, Cyt
TAB-0195CL-F(E)	Anti-Human HER2 Recombinant Antibody Fab Fragment (Anti-HER2-IgGl)	Human	Human antibody	FC, Cyt
VS3-FY665	Recombinant Mouse Anti-ERBB2 Antibody (VS3-FY665)	Human, Mouse, Rat	Mouse IgG	WB, IHC

Creative Quality Control

Our commitment lies in propelling breakthroughs in biopharmaceutical research through the provision of high-quality products and unparalleled customer support. Our strict quality management system ensures that our anti-HER2 recombinant antibodies not only comply with but exceed industry standards. Partner with us to enhance your research and innovation, benefiting from our commitment to quality and customer satisfaction.

Fig.1 SDS-PAGE analysis of TCR-LA-LX0930. (Creative Biolabs Original) Fig.1 SDS-PAGE analysis of Anti-HER2/Neu (KIFGSLAFL) TCR-Like Antibody (SF2), HLA-A2-Restricted.
(Cat# TCR-LA-LX0930, Creative Biolabs)

Customer Reviews

Excellent

Ri***do
Anti-Human HER2 Recombinant Antibody (Anti-HER2-IgGl) (TAB-0195CL)

The product is used for detecting and quantifying HER2 in human extracellular vesicles BT-474 cell lysate. The high specificity and sensitivity of this antibody made me complete the assay in less than 3 hours with good results.

21/Oct/2023 6 Likes

Excellent

Be***zi
Anti-Human HER2 Recombinant Antibody Fab Fragment (TAB-0195CL-F(E))

I acquired this product and employed it to block the HER2/neu signaling pathway in breast cell lines. I was impressed its specific is so excellent. In addition, during the use process, Creative Biolabs also provided comprehensive services to help me determine the optimal concentration and other details. Worthy of praise!

5/Jul/2024 3 Likes

Excellent

Elo**a
Recombinant Mouse Anti-ERBB2 Antibody (VS3-FY665) (VS3-FY665)

I utilized this product to assess the expression level of ERBB2 in various breast cell lines by WB analysis. I observed significantly different positive rates among these cells and no background interference at the suggested concentrations.

26/Mar2024 3 Likes

Anti-HER2 Recombinant Antibody Production

Our advanced serum-free platform streamlines the production of high-quality anti-HER2 recombinant antibodies from gene synthesis through to milligram-to-gram scale output. With a wealth of expertise and experience, we've optimized expression vectors, cloning systems, and high-yielding mammalian cell lines for superior results.

Featured Anti-HER2 Recombinant Antibody Production Platforms

Fig.2 Anti-HER2 recombinant antibody production: milligram-scale. (Creative Biolabs Original) Fig.2 Milligram-scale anti-HER2 recombinant antibody production.

Fig.3 Anti-HER2 recombinant antibody production: gram-scale. (Creative Biolabs Original) Fig.3 Gram-scale anti-HER2 recombinant antibody production.

Anti-HER2 Recombinant Antibody Modalities

Creative Biolabs offers customizable anti-HER2 recombinant antibodies in multiple formats, including full-length, Fab, scFv, etc., to support diverse research needs.

Fig.4 Available anti-HER2 recombinant antibody formats at Creative Biolabs. (Creative Biolabs Original) Fig.4 Full-Length Anti-HER2 Recombinant Antibody Production and Modalities.

Alternative Names

ERBB2; erb-b2 receptor tyrosine kinase 2; TKR1; MLN 19; CD340; NGL; NEU; HER-2/neu; EC 2.7.10.1

Background

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

HER2-Targeted Drug Under Development

Table 1. HER2-targeted drug information (under development).

Company	Highest Phase	Classification	Condition
GC Biopharma Green Cross (GC Biopharma) MacroGenics (Originator) Zai Lab Zai Lab	Launched-2021	Cancer Immunotherapy Chimeric Monoclonal Antibodies	Cancer Cancer, breast Cancer, breast, metastatic Cancer, gastroesophageal junction Cancer, solid tumor Cancer, stomach
Accord Healthcare Intas Pharmaceuticals Shanghai Henlius Biotech (Originator)	Launched-2020	Cancer Immunotherapy Follow-on Products Humanized Monoclonal Antibodies	Cancer, breast Cancer, breast (adenocarcinoma) Cancer, breast, metastatic Cancer, gastroesophageal junction Cancer, stomach, metastatic
AffaMed Therapeutics Daewoong Merck & Co Merck & Co. (Merck & Co) Mundipharma Samsung Bioepis (Originator)	Launched-2018	Biosimilars Cancer Immunotherapy Follow-on Products Humanized Monoclonal Antibodies	Cancer, breast Cancer, breast, metastatic Cancer, gastrointestinal Cancer, stomach, metastatic
BeiGene Jazz Pharmaceuticals Zymeworks (Originator)	Pre-Registered	Bispecific Antibodies Cancer Immunotherapy Humanized Monoclonal Antibodies	Cancer Cancer, biliary Cancer, breast Cancer, endometrium Cancer, gastroesophageal junction (adenocarcinoma) Cancer, gastrointestinal Cancer, hepatobiliary Cancer, lung Cancer, ovary Cancer, solid tumor Cancer, stomach Cancer, stomach, metastatic Esophageal adenocarcinoma

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Launched Drug Information Targeting HER2

Table 2. HER2-targeted drug information (launched).

Company	Highest Phase	Product Category	Condition
Dr Reddy's Laboratories (Originator)	Launched - 2018	Cancer Immunotherapy Follow-on Products Humanized Monoclonal Antibodies Natural Products	Cancer, breast Cancer, breast, metastatic Cancer, stomach, metastatic
Tanvex BioPharma (Originator)	Pre-Registered	Cancer Immunotherapy Follow-on Products Humanized Monoclonal Antibodies	Cancer, breast
SUNHO (China) BioPharmaceutical (Originator)	Phase II/III	Cancer Immunotherapy Monoclonal Antibodies	Cancer, colorectal, metastatic Cancer, solid tumor Digestive-gastrointestinal cancer
Shizuoka Cancer Center (Originator)	Phase II	Cancer Immunotherapy Cancer Vaccines Dendritic Cell Therapy Dendritic Cell Vaccines	Glioblastoma multiforme
Dragonfly Therapeutics (Originator)	Phase II	Bispecific Antibody Fusions Cancer Immunotherapy Fc Fusion Proteins Polypeptides, from 41 AA	Cancer, breast, metastatic Cancer, esophagus Cancer, lung (non-small cell) (NSCLC) Cancer, solid tumor
Triumvira (Originator)	Phase I/II	Cell Therapy	Cancer, gastroesophageal junction Cancer, solid tumor Cancer, stomach

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Creative Biolabs is dedicated to accelerating your research with our high-quality anti-HER2 recombinant antibodies. Please contact us to discover how our anti-HER2 recombinant antibodies can elevate your research. We are eager to collaborate with you and contribute to the success of your scientific endeavors.

Related Diseases

Breast Cancer