Anti-Human HER2 Recombinant Antibody (Anti-HER2-IgGl)
CAT#: TAB-0195CL
The Her2 Antibody-Drug Conjugates comprise a drug moiety, an anti-HER2 antibody and a hydrophilic self-immolative linker. The antibody in this ADC compound specifically target human epidermal growth factor receptor 2 protein (HER2), which is a member of the epidermal growth factor family that are known to play an important role in both development and oncogenesis. Therefore the HER2 ADC can be used in the treatment of breast cancer, gastric cancer and ovarian cancer.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1060/169_D12_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1338/if_selected.jpg
Normal Tissue
Figure 3 IHC staining of human rectum
Immunohistochemical staining of human rectum shows weak cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/ihc_selected.jpg
Normal Tissue
Figure 4 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows moderate cytoplasmic and membranous positivity in urothelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/ihc_selected.jpg
Normal Tissue
Figure 5 Breast
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Myoepithelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/45831_B_3_4.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (OE19, SK-BR-3)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141736-ERBB2
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Specifications
- Host Species
- Human
- Type
- Human antibody
- Specificity
- Human
- Clone
- Anti-HER2-IgGl
- Related Disease
- Breast cancer, gastric cancer, ovarian cancer
Target
- Alternative Names
- HER2; Epidermal growth factor receptor 2 (HER2)
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Related Diseases
Breast Cancer
EGFR Tyrosine Kinase Inhibitor Resistance
Endocrine Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "Clone Anti-HER2-IgGl"
- CAT
- Product Name
See other products for "HER2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0195CL-S(P) | Anti-Human HER2 Recombinant Antibody scFv Fragment (Anti-HER2-IgGl) | FC, Cyt | Human antibody |
| TAB-0195CL-F(E) | Anti-Human HER2 Recombinant Antibody Fab Fragment (Anti-HER2-IgGl) | FC, Cyt | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY665 | Recombinant Mouse Anti-ERBB2 Antibody (VS3-FY665) | WB, IHC | Mouse IgG |
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