Anti-Human HER2 Recombinant Antibody Fab Fragment (Anti-HER2-IgGl)
CAT#: TAB-0195CL-F(E)
The Her2 Antibody-Drug Conjugates comprise a drug moiety, an anti-HER2 antibody and a hydrophilic self-immolative linker. The antibody Fab fragment in the ADC compound specifically targets human epidermal growth factor receptor 2 protein (HER2), which is a member of the epidermal growth factor family that are known to play an important role in both development and oncogenesis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1060/169_D12_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1338/if_selected.jpg
Normal Tissue
Figure 3 IHC staining of human rectum
Immunohistochemical staining of human rectum shows weak cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/ihc_selected.jpg
Normal Tissue
Figure 4 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows moderate cytoplasmic and membranous positivity in urothelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/ihc_selected.jpg
Normal Tissue
Figure 5 Breast
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Myoepithelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/45831_B_3_4.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (OE19, SK-BR-3)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141736-ERBB2
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Specifications
- Host Species
- Human
- Type
- Human antibody
- Specificity
- Human
- Clone
- Anti-HER2-IgGl
- Related Disease
- Breast cancer, gastric cancer, ovarian cancer
Target
- Alternative Names
- HER2; Epidermal growth factor receptor 2 (HER2)
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Related Diseases
Breast Cancer
EGFR Tyrosine Kinase Inhibitor Resistance
Endocrine Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "Clone Anti-HER2-IgGl"
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- Product Name
See other products for "HER2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0195CL | Anti-Human HER2 Recombinant Antibody (Anti-HER2-IgGl) | FC, Cyt | Human antibody |
| TAB-0195CL-S(P) | Anti-Human HER2 Recombinant Antibody scFv Fragment (Anti-HER2-IgGl) | FC, Cyt | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY665 | Recombinant Mouse Anti-ERBB2 Antibody (VS3-FY665) | WB, IHC | Mouse IgG |
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