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MAPK12
Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. Diseases associated with MAPK12 include Breast Cancer and Noonan Syndrome 1. Among its related pathways are Mitochondrial Gene Expression and RANK Signaling in Osteoclasts.
Protein class
Disease related genes, Enzymes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Adipocytes, Astrocytes, Hepatic stellate cells, Endothelial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Low cell line specificity
Interaction
Monomer. Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with SH3BP5. Interacts with LIN7C, SCRIB and SYNJ2BP (By similarity). Interacts with PTPN4; this interaction induces the activation of PTPN4 phosphatase activity.
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
Related Signaling Pathways
FcεR1 Signaling Pathway
TCR Signaling Pathway
Related Diseases
Maturity Onset Diabetes of the Young
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat
- Type: IgG
- Application: WB, IP, ELISA, ICC
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- Species Reactivity: Human
- Application: IHC-P, WB
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: ELISA, WB, IP, ICC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC
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For Research Use Only. Not For Clinical Use.