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For Research Use Only. Not For Clinical Use.


Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated
Protein class

Cancer-related genes, Enzymes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Hepatocytes, Proximal tubular cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (MCF7)

Molecular function

DNA-binding, Methyltransferase, Transferase

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