Anti-MMP13 Recombinant Antibody Products

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Anti-MMP13 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is your premier source for rheumatology and oncology research, and we are proud to offer our high quality and elite anti-MMP13 recombinant antibodies. Matrix Metallopeptidase 13 (MMP13), also known as Collagenase 3, is the most potent and cartilage-degrading collagenase, making it a major target for osteoarthritis therapeutics. Our validated and specific antibodies are powerful tools for understanding its role in joint destruction, as well as in the discovery of novel disease-modifying osteoarthritis drugs (DMOADs).

MMP13: The Cartilage-Degrading Enzyme

Matrix Metallopeptidase 13 (MMP13) or Collagenase 3 is a zinc-dependent, neutral endopeptidase with powerful, cartilage-destroying activity. Its main substrate is Type II collagen, the most abundant component of cartilage extracellular matrix. In adults, MMP13 is undetectable in normal joints. However, osteoarthritis chondrocytes are pathologically stimulated to massively upregulate MMP13 production, resulting in irreversible degradation of the cartilage matrix. This enzymatic erosion of cartilage results in the pain and disability of the disease. MMP13 is overexpressed by various invasive cancers to help them metastasize.

Alternative Names

MMP13; matrix metallopeptidase 13 (collagenase 3); CLG3; MANDP1; MMP-13; collagenase 3; matrix metalloproteinase 13 (collagenase 3)

Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Anti-MMP13 rAb Products

Our anti-MMP13 recombinant antibodies are designed for high specificity and maximum performance. Each clone is rigorously validated to ensure they reliably detect the MMP13 enzyme and do not cross-react with other MMPs. Optimized for IHC on sections of arthritic joints and Western Blot of cell lysates, our rAbs will perform in your applications with the consistent quality you expect for your research.

Table 1. Featured anti-MMP13 recombinant antibody products at Creative Biolabs.

Customer Reviews

Excellent

S**ra
Human Anti-MMP13 Recombinant Antibody (TAB-0820CL)

The quality of Creative Biolabs' reagents is excellent. Their anti-MMP13 antibody has been a reliable and crucial part of our research into new DMOADs.

11/Oct/2023

rAb Production

Creative Biolabs is committed to supporting the specialized field of rheumatology by providing you with the highest quality tools to take your research further. Our anti-MMP13 recombinant antibodies are expressed in highly optimized systems to ensure they recognize the native form of the enzyme and provide you with a specific, active antibody for your experiments.

Featured Anti-MMP13 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-MMP13 recombinant antibody production.

Fig.2 Gram-scale anti-MMP13 recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to enabling scientific discovery by providing you with a suite of antibody modalities to fit your needs. Our anti-MMP13 recombinant antibodies are available in a variety of formats that are customizable to your experimental requirements, including functional blocking clones.

Fig.3 Full-length anti-MMP13 recombinant antibody production and modalities.

Highly specific, rigorously validated reagents are critical for dissecting the role of MMP13 in cartilage degradation, and Creative Biolabs has the solutions for your rheumatology research. Our anti-MMP13 recombinant antibodies have been engineered for top quality, ensuring you receive a reliable antibody with maximum performance for your applications. Contact our experts today for help finding the ideal tool for your osteoarthritis research.