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NEDD9
Loading...Anti-NEDD9 Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: WB, ELISA, ICC, IF, IP
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- Anti-NEDD9 Immunohistochemistry Kit (VS-0525-XY4770)
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- Species Reactivity: Human
- Target: NEDD9
- Application: IHC
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- Mouse Anti-NEDD9 Recombinant Antibody (clone 3F7A9) (VS7-0425-WR461)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, FC
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For Research Use Only. Not For Clinical Use.
Background
Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Alveolar cells type 1, Glandular and luminal cells, Adipocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (EFO-21, HSkMC)
Interaction
Homodimer. Can heterodimerize with HLH proteins ID2, E12, E47 and also with p130cas. Forms complexes in vivo with related adhesion focal tyrosine kinase (RAFTK), adapter protein CRKL and LYN kinase. Interacts with MICAL and TXNL4/DIM1. Interacts with BCAR3 (via Ras-GEF domain) (By similarity). Interacts with SH2D3C isoform 1 and isoform 2 (By similarity).
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