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NPC2
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- Recombinant Mouse Anti-Human NPC2 Antibody (MOB-1717MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
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- Mouse Anti-NPC2 Recombinant Antibody (clone 3-6B) (HPAB-0225-LSX)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, WB
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- AbPlus™ Anti-NPC2 Magnetic Beads (VS-0724-YC1357) (VS-0724-YC1357)
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- Target: NPC2
- Target Species: Human
- Application: IP, Protein Purification
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- Mouse Anti-NPC2 Recombinant Antibody (clone 3-6B); scFv Fragment (HPAB-0225-LSX-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB, EIA
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- Mouse Anti-NPC2 Recombinant Antibody (clone 3-6B); Fab Fragment (HPAB-0225-LSX-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB, EIA
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- Rabbit Anti-NPC2 Recombinant Antibody (VS13-YC834) (VS13-YC834)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P
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- Anti-NPC2 Immunohistochemistry Kit (VS-0525-XY4916)
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- Species Reactivity: Human
- Target: NPC2
- Application: IHC
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- Anti-Mouse NPC2 Immunohistochemistry Kit (VS-0525-XY4917)
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- Species Reactivity: Human, Mouse, Rat
- Target: NPC2
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy.
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Hofbauer cells, Kupffer cells, Alveolar cells type 2)
Immune cell specificity
Group enriched (plasmacytoid DC, intermediate monocyte, classical monocyte, non-classical monocyte, neutrophil, basophil, myeloid DC)
Cell line specificity
Cell line enhanced (ASC diff)
Interaction
Interacts with NPC1 (via the second lumenal domain) in a cholestrol-dependent manner (PubMed:18772377, PubMed:27238017, PubMed:27551080). Interacts with NUS1/NgBR, the interaction stabilizes NCP2 and regulates cholesterol trafficking (PubMed:19723497). Interacts with DHDDS (PubMed:15110773). Interacts with NEDD4L (via C2 domain) (PubMed:19664597). Interacts with NPC1L1 (PubMed:22095670).
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