Rabbit Anti-NPC2 Recombinant Antibody (clone R07-0C8) (CAT#: VS3-FY2048)

• Immunogen
• Recombinant human Niemann Pick C2 protein

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat NPC2

• Species Reactivity
• Human, Mouse, Rat

• Clone
• R07-0C8

• Applications
• Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence

• MW
• The calculated weight of the target protein is approximately 17 kDa, while the observed molecular weight stands at 17 kDa.

• Related Disease
• Niemann-Pick disease, type C2 and frontal lobe atrophy

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA

• Preservative
• 0.01% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/100
  Immunofluorescence: 1/50-1/200

• Alternative Names
• NPC Intracellular Cholesterol Transporter 2; Niemann-Pick Disease Type C2 Protein; Human Epididymis-Specific Protein 1; Epididymal Protein 1; HE1; Tissue-Specific Secretory Protein; Epididymal Secretory Protein E1; Niemann-Pick Disease, Type C2; EDDM1

• Gene ID
• 10577

• UniProt ID
• P61916

• Sequence Similarities
• Belongs to the NPC2 family.

• Cellular Localization
• Endoplasmic reticulum, Lysosome, Secreted

• Post Translation Modifications
• Glycosylation at Asn58 and Asn135 (NX_P61916 [NX_P61916-1])
  Modification sites at PhosphoSitePlus (P61916)
  Glycosylation from GlyConnect NPC2_HUMAN (1215)
  Glycosylation from GlyGen (P61916) 3 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site)

• Protein Refseq
• NP_001350617.1; NP_001362369.1; NP_006423.1

• Function
• Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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