Rabbit Anti-NPC2 Recombinant Antibody (clone R07-0C8) (CAT#: VS3-FY2048)
Clone R07-0C8 is a rabbit IgG recombinant monoclonal antibody that is specifically designed to target human NPC2 protein, a calculated weight of 17 kDa. It cross-reacts with mouse, rat. It is suitable for use in a variety of assays, including WB, IHC-F, IHC-P, ICC/IF.
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WB
Figure 1 Anti-NPC2 Antibody (VS3-FY2048) in WB.
The Niemann Pick C2 expression in Raw264.7, PC-12, C6 lysates were detected using the anti-Niemann Pick C2 by western blot assay.
ICC
Figure 2 Anti-NPC2 Antibody (VS3-FY2048) in ICC.
Immunocytochemistry staining of Niemann Pick C2 (green) in U87-MG using the anti-Niemann Pick C2 antibody. Nuclear DNA was labeled with DAPI (shown in blue).
Specifications
- Immunogen
- Recombinant human Niemann Pick C2 protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat NPC2
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R07-0C8
- Applications
- Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence
- MW
- The calculated weight of the target protein is approximately 17 kDa, while the observed molecular weight stands at 17 kDa.
- Related Disease
- Niemann-Pick disease, type C2 and frontal lobe atrophy
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunofluorescence: 1/50-1/200
Target
- Alternative Names
- NPC Intracellular Cholesterol Transporter 2; Niemann-Pick Disease Type C2 Protein; Human Epididymis-Specific Protein 1; Epididymal Protein 1; HE1; Tissue-Specific Secretory Protein; Epididymal Secretory Protein E1; Niemann-Pick Disease, Type C2; EDDM1
- Gene ID
- 10577
- UniProt ID
- P61916
- Sequence Similarities
- Belongs to the NPC2 family.
- Cellular Localization
- Endoplasmic reticulum, Lysosome, Secreted
- Post Translation Modifications
- Glycosylation at Asn58 and Asn135 (NX_P61916 [NX_P61916-1])
Modification sites at PhosphoSitePlus (P61916)
Glycosylation from GlyConnect NPC2_HUMAN (1215)
Glycosylation from GlyGen (P61916) 3 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001350617.1; NP_001362369.1; NP_006423.1
- Function
- Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1717MZ | Recombinant Mouse Anti-Human NPC2 Antibody | ELISA, WB | Mouse antibody |
| HPAB-0225-LSX | Mouse Anti-NPC2 Recombinant Antibody (clone 3-6B) | ELISA, WB | Mouse IgG2a |
| VS13-YC834 | Rabbit Anti-NPC2 Recombinant Antibody (VS13-YC834) | WB, IHC-P | Rabbit IgG |
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