Rabbit Anti-NPC2 Recombinant Antibody (VS13-YC834) (CAT#: VS13-YC834)
The Rabbit Anti-NPC2 Recombinant Antibody is specific for human, mouse and rat NPC2. NPC2 encodes a lipid recognition protein involved in cholesterol transport, with mutations causing a form of Niemann-Pick disease. The anti-NPC2 antibody can be used for Western blot (1/500-1/1000), Immunohistochemistry (1/50-1/100).
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Normal Tissue
RNA Expression
Figure 1 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32888/168989_A_8_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32888/168989_A_8_4.jpg
Figure 2 Kidney
(Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32888/168989_A_7_5.jpg
(Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32888/168989_A_7_5.jpg
Figure 3 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32888/168989_A_5_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32888/168989_A_5_6.jpg
Figure 4 Epididymis
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32888/168989_A_3_6.jpg
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32888/168989_A_3_6.jpg
Figure 5 RNA cell line category: Cell line enhanced (ASC diff)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000119655-NPC2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000119655-NPC2
Specifications
- Immunogen
- Recombinant human Niemann Pick C2.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat NPC2
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC-P
- Conjugate
- NONE
- Related Disease
- Niemann-Pick disease, type C2 and Frontal lobe atrophy
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunohistochemistry (IHC): 1/50-1/100
Target
- Alternative Names
- NPC Intracellular Cholesterol Transporter 2; Niemann-Pick Disease Type C2 Protein; Human Epididymis-Specific Protein 1; Epididymal Protein 1; HE1; Tissue-Specific Secretory Protein; Epididymal Secretory Protein E1; Niemann-Pick Disease, Type C2; EDDM1;
- Gene ID
- 10577
- UniProt ID
- P61916
- Long Name
- NPC Intracellular Cholesterol Transporter 2
- Sequence Similarities
- Belongs to the NPC2 family.
- Cellular Localization
- Endoplasmic reticulum; Lysosome; Secreted
- Protein Refseq
- NP_001350617.1; NP_001362369.1; NP_006423.1
- Function
- Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1717MZ | Recombinant Mouse Anti-Human NPC2 Antibody | ELISA, WB | Mouse antibody |
| HPAB-0225-LSX | Mouse Anti-NPC2 Recombinant Antibody (clone 3-6B) | ELISA, WB | Mouse IgG2a |
| VS3-FY2048 | Rabbit Anti-NPC2 Recombinant Antibody (clone R07-0C8) | WB, IHC-Fr, IHC-P, IF | Rabbit IgG |
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