Rabbit Anti-NPC2 Recombinant Antibody (VS13-YC834)
CAT#: VS13-YC834
The Rabbit Anti-NPC2 Recombinant Antibody is specific for human, mouse and rat NPC2. NPC2 encodes a lipid recognition protein involved in cholesterol transport, with mutations causing a form of Niemann-Pick disease. The anti-NPC2 antibody can be used for Western blot (1/500-1/1000), Immunohistochemistry (1/50-1/100).
Gene Expression
Normal Tissue
Figure 1 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32888/168989_A_8_4.jpg
Normal Tissue
Figure 2 Kidney
Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32888/168989_A_7_5.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32888/168989_A_5_6.jpg
Normal Tissue
Figure 4 Epididymis
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32888/168989_A_3_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (ASC diff)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000119655-NPC2
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Specifications
- Immunogen
- Recombinant human Niemann Pick C2.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat NPC2
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC-P
- Conjugate
- NONE
- Related Disease
- Niemann-Pick disease, type C2 and Frontal lobe atrophy
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunohistochemistry (IHC): 1/50-1/100
Target
- Alternative Names
- NPC Intracellular Cholesterol Transporter 2; Niemann-Pick Disease Type C2 Protein; Human Epididymis-Specific Protein 1; Epididymal Protein 1; HE1; Tissue-Specific Secretory Protein; Epididymal Secretory Protein E1; Niemann-Pick Disease, Type C2; EDDM1;
- Gene ID
- 10577
- UniProt ID
- P61916
- Long Name
- NPC Intracellular Cholesterol Transporter 2
- Sequence Similarities
- Belongs to the NPC2 family.
- Cellular Localization
- Endoplasmic reticulum; Lysosome; Secreted
- Protein Refseq
- NP_001350617.1; NP_001362369.1; NP_006423.1
- Function
- Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "NPC2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1717MZ | Recombinant Mouse Anti-Human NPC2 Antibody | ELISA, WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4348 | Hi-Affi™ Recombinant Rabbit Anti-NPC2 Monoclonal Antibody (SI438DS) | WB, ELISA, IP | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0225-LSX | Mouse Anti-NPC2 Recombinant Antibody (clone 3-6B) | ELISA, WB | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0225-LSX-S(P) | Mouse Anti-NPC2 Recombinant Antibody (clone 3-6B); scFv Fragment | ELISA, WB, EIA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0225-LSX-F(E) | Mouse Anti-NPC2 Recombinant Antibody (clone 3-6B); Fab Fragment | ELISA, WB, EIA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY2048 | Rabbit Anti-NPC2 Recombinant Antibody (clone R07-0C8) | WB, IHC-Fr, IHC-P, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1357 | AbPlus™ Anti-NPC2 Magnetic Beads (VS-0724-YC1357) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4916 | Anti-NPC2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4917 | Anti-Mouse NPC2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC237 | Recombinant Anti-NPC2 Eliminating Antibody, pH-Sensitive (3-6B var.) | Antigen-Sweeping In Vivo. | Mouse IgG2a |
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