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NR2C2
This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms.
Protein class
Nuclear receptors, Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer; can bind DNA as homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C1 required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats. Interacts with PCAF; the interaction preferentially occurs on the non-phosphorylated form and induces NR2C2-mediated transactivation activity and does not require the ligand-binding domain (By similarity). Interacts (MAPK-mediated phosphorylated form) with NRIP1; the interaction promotes repression of NR2C2-mediated activity (PubMed:9556573). Interacts with NR2C2AP; the interaction represses selective NR2C2-mediated transcriptional activity (PubMed:12486131). Interacts with NLRP10 (PubMed:22672233). Interacts (via ligand-binding region) with transcriptional corepressor JAZF1; the interaction promotes NR2C2-mediated transcriptional repression (PubMed:15302918).
Molecular function
Activator, DNA-binding, Receptor, Repressor
More Types Infomation
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- Species Reactivity: Human
- Application: IHC-P, WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: IP, WB
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- Derivation: Human
- Species Reactivity: Human
- Type: Human IgG
- Application: WB, ELISA, IHC, IP
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- Derivation: Human
- Species Reactivity: Human
- Type: Human IgG
- Application: WB, ELISA, IHC, IP
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB
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- Derivation: Human
- Species Reactivity: Human
- Type: Human scFv
- Application: WB, ELISA, IHC, IP
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- Derivation: Human
- Species Reactivity: Human
- Type: Human scFv
- Application: WB, ELISA, IHC, IP
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA, IHC, IP
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA, IHC, IP
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For Research Use Only. Not For Clinical Use.