Mouse Anti-NR2C2 Recombinant Antibody (VS3-FY2824)
CAT#: VS3-FY2824
This anti-NR2C2 product is a mouse recombinant monoclonal antibody that is created to recognize human, mouse, rat NR2C2 protein, a calculated molecular weight of the protein is about 65.4 kDa. This monoclonal antibody proves valuable in disease research related to Premature Aging. The antibody can be utilized for detection of NR2C2 by Western Blot (1/500-1/1000).
Gene Expression
Normal Tissue
Figure 1 IHC staining of human endometrium
Immunohistochemical staining of human endometrium shows nuclear positivity in glandular cells and cels in the endometrial stroma.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6313/17445_B_4_3_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6313/17445_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6313/17445_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6313/17445_A_8_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6313/17445_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6313/17445_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6313/17445_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000177463-NR2C2
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human, Mouse and Rat NR2C2
- Species Reactivity
- Human, Mouse, Rat
- Applications
- Western Blot
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 65.4 kDa.
- Related Disease
- Premature Aging
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Nuclear Receptor Subfamily 2 Group C Member 2; Orphan Nuclear Receptor TAK1; Orphan Nuclear Receptor TR4; TAK1; TR4; Nuclear Receptor Subfamily 2, Group C, Member 2
- Gene ID
- 7182
- UniProt ID
- P49116
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity.
Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas the non-phosphorylated form preferentially recruits the coactivator, PCAF.
- Protein Refseq
- XP_011532361.1; XP_011532360.1
- Function
- Orphan nuclear receptor that can act as a repressor or activator of transcription.
An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways.
May regulate gene expression during the late phase of spermatogenesis.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "NR2C2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1450CT | Recombinant Mouse anti-Human NR2C2 Monoclonal antibody (EML2388) | IHC-P, WB | |
| VS3-XY3453 | Rabbit Anti-NR2C2 Recombinant Antibody (clone R78-4M-2) | WB | Rabbit IgG |
| VS7-0425-WR502 | Mouse Anti-NR2C2 Recombinant Antibody (clone 8F2E8) | FC | Mouse IgG1 |
| VS7-0425-WR503 | Mouse Anti-NR2C2 Recombinant Antibody (clone 8H11D4) | FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2490 | Hi-Affi™ Recombinant Rabbit Anti-NR2C2 Monoclonal Antibody (DS2490AB) | IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-093CN | Human Anti-NR2C2 Recombinant Antibody (clone T1014F08) | WB, ELISA, IHC, IP | Human IgG |
| NS-094CN | Human Anti-NR2C2 Recombinant Antibody (clone T1014G03) | WB, ELISA, IHC, IP | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-093CN-F(E) | Human Anti-NR2C2 Recombinant Antibody (clone T1014F08); Fab Fragment | WB, ELISA, IHC, IP | Human Fab |
| NS-094CN-F(E) | Human Anti-NR2C2 Recombinant Antibody (clone T1014G03); Fab Fragment | WB, ELISA, IHC, IP | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-093CN-S(P) | Human Anti-NR2C2 Recombinant Antibody (clone T1014F08); scFv Fragment | WB, ELISA, IHC, IP | Human scFv |
| NS-094CN-S(P) | Human Anti-NR2C2 Recombinant Antibody (clone T1014G03); scFv Fragment | WB, ELISA, IHC, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY204 | AbPlus™ Anti-NR2C2 Magnetic Beads (T1014F08) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4951 | Anti-NR2C2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4952 | Anti-Mouse NR2C2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4953 | Anti-Rat NR2C2 Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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