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    Mouse Anti-NR2C2 Recombinant Antibody (VS3-FY2824) (CAT#: VS3-FY2824)

    This anti-NR2C2 product is a mouse recombinant monoclonal antibody that is created to recognize human, mouse, rat NR2C2 protein, a calculated molecular weight of the protein is about 65.4 kDa. This monoclonal antibody proves valuable in disease research related to Premature Aging. The antibody can be utilized for detection of NR2C2 by Western Blot (1/500-1/1000).

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 IHC staining of human endometrium
    Figure 1 IHC staining of human endometrium
    (Immunohistochemical staining of human endometrium shows nuclear positivity in glandular cells and cels in the endometrial stroma.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/6313/17445_B_4_3_selected.jpg
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/6313/17445_B_7_5.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/6313/17445_A_8_3.jpg
    Figure 4 Liver
    Figure 4 Liver
    (Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/6313/17445_A_8_4.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/6313/17445_A_7_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/6313/17445_A_6_6.jpg
    Figure 7 Lymph node
    Figure 7 Lymph node
    (Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/6313/17445_A_8_8.jpg
    RNA Expression
    Figure 8 RNA cell line category: Low cell line specificity
    Figure 8 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000177463-NR2C2

    Specifications

    • Host Species
    • Mouse
    • Type
    • Mouse IgG
    • Specificity
    • Human, Mouse and Rat NR2C2
    • Species Reactivity
    • Human, Mouse, Rat
    • Applications
    • Western Blot
    • Conjugate
    • Unconjugated, FITC
    • MW
    • The molecular weight of the target protein is approximately 65.4 kDa.
    • Related Disease
    • Premature Aging

    Product Property

    • Clonality
    • Monoclonal Antibody
    • Format
    • Liquid
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

    Applications

    • Application Notes
    • Western Blot: 1/500-1/1000

    Target

    • Alternative Names
    • Nuclear Receptor Subfamily 2 Group C Member 2; Orphan Nuclear Receptor TAK1; Orphan Nuclear Receptor TR4; TAK1; TR4; Nuclear Receptor Subfamily 2, Group C, Member 2
    • Cellular Localization
    • Nucleus
    • Post Translation Modifications
    • Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity.
      Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas the non-phosphorylated form preferentially recruits the coactivator, PCAF.
    • Function
    • Orphan nuclear receptor that can act as a repressor or activator of transcription.
      An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways.
      May regulate gene expression during the late phase of spermatogenesis.

    Recommended Products

    Secondary Antibody

    Isotype Control

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "NR2C2"

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    CAT Product Name Application Type
    MOB-1450CT Recombinant Mouse anti-Human NR2C2 Monoclonal antibody (EML2388) IHC-P, WB
    VS3-XY3453 Rabbit Anti-NR2C2 Recombinant Antibody (clone R78-4M-2) WB Rabbit IgG
    VS7-0425-WR502 Mouse Anti-NR2C2 Recombinant Antibody (clone 8F2E8) FC Mouse IgG1
    VS7-0425-WR503 Mouse Anti-NR2C2 Recombinant Antibody (clone 8H11D4) FC Mouse IgG1

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