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    P4HB

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    Anti-P4HB Products

    • Recombinant Mouse Anti-P4hb Antibody (RL77) (NEUT-1823CQ)
      • Species Reactivity: Human, Mouse, Pig, Rat, Hamster, Primate, Xenopus laevis
      • Type: IgG2b
      • Application: BL, ELISA, FC, GSA, ICC/IF, IHC, IHC-P, IP, WB
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    • Recombinant Mouse Anti-P4hb Antibody (RL90) (NEUT-1824CQ)
      • Species Reactivity: Human, Mouse, Pig, Rat, Hamster, Primate, Rabbit, Bovine
      • Type: IgG2a
      • Application: BL, ELISA, FC, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB
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    For Research Use Only. Not For Clinical Use.


    This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
    Protein class

    Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Extravillous trophoblasts, Exocrine glandular cells)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Low cell line specificity

    Interaction

    Heterodimer; heterodimerizes with the protein microsomal triglyceride transfer MTTP (PubMed:23475612, PubMed:26224785, PubMed:16478722). Homodimer. Monomers and homotetramers may also occur. Interacts with P4HA2, forming a heterotetramer consisting of 2 alpha subunits (P4HA2) and 2 beta (P4HB), where P4HB plays the role of a structural subunit; this tetramer catalyzes the formation of 4-hydroxyproline in collagen (PubMed:7753822). Also constitutes the structural subunit of the microsomal triacylglycerol transfer protein MTTP in mammalian cells. Stabilizes both enzymes and retain them in the ER without contributing to the catalytic activity (By similarity). Binds UBQLN1 (PubMed:12095988). Interacts with ERO1B (PubMed:11707400). Binds to CD4, and upon HIV-1 binding to the cell membrane, is part of a P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with ILDR2 (By similarity).

    Molecular function

    Chaperone, Isomerase

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