Anti-PDE2A Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is at the forefront of cardiovascular and neuroscience research. Here you can find high quality, specific anti-PDE2A recombinant antibodies, the gold standard research tools for unraveling its function in cardiac and brain health. PDE2A is a dual-specificity phosphodiesterase (PDE) enzyme that degrades both cAMP and cGMP. Our recombinant antibodies are essential for your research to uncover its function and regulation in cardiac contractility, neuronal plasticity, adrenal steroidogenesis, and for the discovery of new target therapies.

PDE2A: The cGMP-Stimulated Cyclic Nucleotide Phosphodiesterase

Phosphodiesterase 2A (PDE2A) belongs to the phosphodiesterase superfamily of enzymes, which catabolize the intracellular second messengers cyclic AMP (cAMP) and cyclic GMP (cGMP). PDE2A is the first cGMP-regulated cyclic nucleotide PDE that was purified and its biochemical properties described. As a dual-specificity enzyme, PDE2A can degrade both cAMP and cGMP. The activity of PDE2A is allosterically regulated by the binding of cGMP to its GAF domains. This leads to an intriguing signaling crosstalk: a rise in cGMP (e.g. resulting from NO signaling) results in the activation of PDE2A, which then causes a transient degradation of cAMP, providing important control of heart rate, adrenal steroid production, and neuronal activity.

Alternative Names

PDE2A; phosphodiesterase 2A, cGMP-stimulated; PDE2A1; PED2A4; cGSPDE; CGS-PDE; cGMP-dependent 3,5-cyclic phosphodiesterase; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 4; cyclic GMP-stimulated phosphodiesterase;

Background

Enables several functions, including 3',5'-cyclic-nucleotide phosphodiesterase activity; anion binding activity; and metal ion binding activity. Involved in several processes, including cellular response to organic cyclic compound; cyclic-nucleotide-mediated signaling; and regulation of vascular permeability. Located in several cellular components, including cytosol; mitochondrial membrane; and perinuclear region of cytoplasm. Colocalizes with plasma membrane.

Anti-PDE2A rAb Products

Creative Biolabs' anti-PDE2A recombinant antibodies are engineered to be ultra-specific to the PDE2A protein. They are validated to ensure reliable detection of the PDE2A enzyme. Optimized for Western Blot analysis to study its expression in various tissues and for IHC to precisely determine its localization in heart and brain tissue, our rAbs are among the best tools to facilitate detailed signaling studies.

Table 1. Featured anti-PDE2A recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is committed to making the drug discovery process faster, and to this end we use the latest production technologies. Our anti-PDE2A recombinant antibodies are developed with the utmost care and attention to detail to ensure the highest level of specificity and sensitivity for this critical signaling protein.

Featured Anti-PDE2A Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-PDE2A recombinant antibody production.

Fig.2 Gram-scale anti-PDE2A recombinant antibody production.

rAb Modalities

Creative Biolabs is passionate about offering the research community innovative and versatile tools. Our anti-PDE2A antibodies are available in many different modalities to support as many experimental applications as possible to study this important enzyme.

Fig.3 Full-length anti-PDE2A recombinant antibody production and modalities.

Let Creative Biolabs' world-class anti-PDE2A recombinant antibodies take your research to the next level. We pride ourselves on our antibodies' unmatched isoform specificity and strict validation to make them the best tools for drug discovery and basic cell biology. Our expert team is ready to assist you. Reach out today.