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  • Recombinant Rabbit Anti-PDE2A Antibody (clone 11C6)

Recombinant Rabbit Anti-PDE2A Antibody (clone 11C6) (CAT#: VS4-CJ69)

This rabbit anti-PDE2A antibody (clone 11C6) is a product that recognizes human PDE2A. The immunogen of this antibody is a synthesized peptide derived from human PDE2A. The mAb has been tested for use in ELISA, Immunofluorescence (1:50-1:200).


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Subcellular Location
Figure 1 IF staining of human cell line PC-3
Figure 1 IF staining of human cell line PC-3
(Immunofluorescent staining of human cell line PC-3 shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/9752/1020_G2_4_selected.jpg
Normal Tissue
Figure 2 Spleen
Figure 2 Spleen
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31192/144618_B_7_4_val_selected.jpg
Figure 3 IHC staining of human cerebral cortex
Figure 3 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows distinct nuclear and cytoplasmic positivity in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/9752/ihc_selected.jpg
Figure 4 Cerebral cortex
Figure 4 Cerebral cortex
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/9752/32523_B_7_5.jpg
Figure 5 Colon
Figure 5 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31192/144618_A_9_3.jpg
Figure 6 Kidney
Figure 6 Kidney
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31192/144618_A_7_5.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enriched (HeLa)
Figure 7 RNA cell line category: Cell line enriched (HeLa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000186642-PDE2A

Specifications

  • Immunogen
  • A synthesized peptide derived from human PDE2A
  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human PDE2A
  • Species Reactivity
  • Human
  • Clone
  • 11C6
  • Applications
  • ELISA, IF
  • Conjugate
  • Unconjugated

Product Property

  • Purification
  • Affinity chromatography
  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Buffer
  • 50% Glycerol, 150 mM NaCl, PBS, pH 7.4.
  • Preservative
  • 0.02% Sodium Azide
  • Storage
  • Store at -20°C or -80°C upon receipt. Avoid repeated freeze.

Applications

  • Application Notes
  • This antibody has been tested for use in ELISA, Immunofluorescence (1:50-1:200).

Target

  • Alternative Names
  • PDE2A1; PED2A4; cGSPDE; CGS-PDE; IDDPADS
  • Long Name
  • Phosphodiesterase 2A
  • Sequence Similarities
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.
  • Cellular Localization
  • Cell membrane, Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane
  • Function
  • cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:9210593, PubMed:29392776, PubMed:15938621).
    Has a higher efficiency with cGMP compared to cAMP (PubMed:15938621).
    Plays a role in cell growth and migration (PubMed:24705027).
    Isoform PDE2A2:
    Regulates mitochondrial cAMP levels and respiration (By similarity).
    Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107).

Recommended Products

Isotype Control

Secondary Antibody

Recommended Dilution Buffer

Related Resources

  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "PDE2A"

Recombinant Antibody

CAT Product Name Application Type
MOB-1326CT Recombinant Mouse anti-Human PDE2A Monoclonal antibody (EML598) WB

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2629 Hi-Affi™ Recombinant Rabbit Anti-PDE2A Monoclonal Antibody (DS2629AB) WB IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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