Recombinant Rabbit Anti-PDE2A Antibody (clone 11C6)
CAT#: VS4-CJ69
This rabbit anti-PDE2A antibody (clone 11C6) is a product that recognizes human PDE2A. The immunogen of this antibody is a synthesized peptide derived from human PDE2A. The mAb has been tested for use in ELISA, Immunofluorescence (1:50-1:200).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9752/1020_G2_4_selected.jpg
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Specifications
- Immunogen
- A synthesized peptide derived from human PDE2A
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human PDE2A
- Species Reactivity
- Human
- Clone
- 11C6
- Applications
- ELISA, IF
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 150 mM NaCl, PBS, pH 7.4.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Immunofluorescence (1:50-1:200).
Target
- Alternative Names
- PDE2A1; PED2A4; cGSPDE; CGS-PDE; IDDPADS
- Gene ID
- 5138
- UniProt ID
- O00408
- Long Name
- Phosphodiesterase 2A
- Sequence Similarities
- Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.
- Cellular Localization
- Cell membrane, Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane
- Protein Refseq
- NP_001137311.1; NP_001139681.1; NP_001230713.1
- Function
- cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:9210593, PubMed:29392776, PubMed:15938621).
Has a higher efficiency with cGMP compared to cAMP (PubMed:15938621).
Plays a role in cell growth and migration (PubMed:24705027).
Isoform PDE2A2:
Regulates mitochondrial cAMP levels and respiration (By similarity).
Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107).
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Related Signaling Pathways
cAMP Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "PDE2A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1326CT | Recombinant Mouse anti-Human PDE2A Monoclonal antibody (EML598) | WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2629 | Hi-Affi™ Recombinant Rabbit Anti-PDE2A Monoclonal Antibody (DS2629AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5266 | Anti-PDE2A Immunohistochemistry Kit | IHC |
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