Anti-PDE4B Recombinant Antibody Products

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Anti-PDE4B Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is at the forefront of developing innovative PDE4B-specific recombinant antibodies that propel transformative progress in life science research. Our integrated antibody engineering platform unites cutting-edge molecular design with stringent quality validation, delivering consistently reliable reagents that fulfill the most exacting research standards. Researchers can leverage our meticulously curated portfolio of optimized antibody solutions, each precisely engineered to surmount methodological challenges across diverse therapeutic areas. We surpass conventional vendor roles by offering personalized scientific collaboration—encompassing initial experimental planning through to data interpretation—with dedicated specialists providing tailored protocol modifications and technical guidance aligned with your project’s unique requirements. This distinctive synergy of premium antibody tools and proactive research partnership cultivates an optimal ecosystem for translating pioneering concepts into impactful scientific breakthroughs.

PDE4B: A Promising Therapeutic Target in Inflammatory Neurological and Cancer Disorders

PDE4B is an enzyme that plays a pivotal role in regulating intracellular cyclic AMP (cAMP) levels, which are critical for numerous cellular functions including inflammatory responses, immune regulation, and neural signaling. Aberrant PDE4B activity has been linked to a variety of diseases, particularly those involving inflammation and the nervous system. Elevated PDE4B expression is associated with chronic inflammatory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and rheumatoid arthritis, where it contributes to excessive immune activation and tissue damage. In the brain, altered PDE4B function affects neurotransmitter signaling and has been implicated in psychiatric disorders including schizophrenia, depression, and anxiety, influencing cognitive and mood regulation. Moreover, PDE4B has emerged as a factor in cancer biology, where its dysregulation may promote tumor growth and metastasis through effects on cell proliferation and survival pathways. Given its broad involvement in disease processes, PDE4B is considered a promising target for therapeutic intervention. Several PDE4 inhibitors targeting PDE4B are under development or clinical use to treat inflammatory and neuropsychiatric disorders. Ongoing research aims to better understand PDE4B’s mechanisms and improve targeted therapies, offering hope for more effective treatments across a spectrum of conditions.

Alternative Names

Complement DPDE4; PDEIVB; cAMP-specific 3', 5'-cyclic phosphodiesterase 4B

Background

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms.

Anti-PDE4B rAb Products

We accelerate research progress by offering premium anti-PDE4B recombinant antibodies that deliver exceptional target affinity, economic value, and end-to-end scientific support. These precision reagents facilitate reliable experimental replication, complemented by our experts' customized advisory services to refine methodology and enhance investigation efficiency.

Table 1. Featured anti-PDE4B recombinant antibody products at Creative Biolabs.

Customer Reviews

Excellent

M**ew
Rabbit Anti-PDE4B Antibody (VS-0722-YJ175) (CAT#: VS1-YJ175)

In our immunoprecipitation experiments with human lung epithelial cell lysates, the Rabbit Anti-PDE4B Antibody exhibited excellent target selectivity and binding efficiency, successfully isolating the protein with negligible non-specific interactions. The reagent consistently delivered reproducible results across technical replicates and adapted seamlessly to our established immunoprecipitation workflow without protocol modifications. These characteristics establish it as a robust and trustworthy tool for PDE4B protein complex isolation studies.

14/Mar/2024

Excellent

As**y
Mouse Anti-PDE4B Recombinant Antibody (clone 1D12) (CAT#: VS-0224-XY99)

In our experiments, the Mouse Anti-PDE4B Recombinant Antibody was applied to flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs). The antibody provided clear and specific staining with low background levels. It was easy to use and gave consistent results across different samples without extensive optimization. Overall, this antibody proved to be a reliable tool for detecting PDE4B in FC assays.

26/Aug/2023

Excellent

C**er
CytoStream™ Rabbit Anti-PDE4B Recombinant Antibody (VS13-YC883) (CAT#: VS13-YC883)

We evaluated the CytoStream™ Rabbit Anti-PDE4B Recombinant Antibody using Western blot on mouse brain tissue lysates. The antibody showed specific binding with clear bands and minimal background. It performed consistently across multiple tests and worked well without needing protocol changes. This antibody is a solid choice for PDE4B detection in WB applications.

19/Nov/2023

rAb Production

Drawing on decades of specialized proficiency in engineered antibody development, we offer rigorously validated research reagents backed by responsive customer support, designed to facilitate accelerated project timelines that are precisely tailored to your unique experimental needs and objectives.

Featured Anti-PDE4B Recombinant Antibody Production Platforms
Fig.1 Milligram-scale recombinant antibody production.

Fig.2 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs empowers scientists with an extensive portfolio of innovative recombinant antibodies available in diverse configurations, developed through our mastery of advanced antibody modification technologies. Our specialists excel in creating tailored research solutions, with each antibody product complemented by fully customizable development services precisely addressing your project's specific biological challenges and experimental objectives.

Fig.3 Full Length Anti-PDE4B Recombinant Antibody Production and Modalities.

For additional technical details concerning the PDE4B target, our expert support staff welcomes your correspondence through either phone or email. We stand ready to troubleshoot experimental challenges and offer customized solutions to ensure your research achieves optimal results - please don't hesitate to reach out to us for personalized assistance.

Related Signaling Pathways

cAMP Signaling Pathway