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PERP

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For Research Use Only. Not For Clinical Use.


Background

Involved in activation of cysteine-type endopeptidase activity and positive regulation of neutrophil chemotaxis. Predicted to be located in desmosome and plasma membrane. Predicted to be active in cell-cell junction. Implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques.
Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Suprabasal keratinocytes, Squamous epithelial cells, Basal keratinocytes)

Immune cell specificity

Immune cell enriched (basophil)

Cell line specificity

Cell line enhanced (hTCEpi)

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