Anti-RANKL Recombinant Antibody Products

Creative Biolabs offers a comprehensive range of high-quality recombinant antibodies targeting RANKL, specifically developed for both research investigations and clinical implementation. Our custom solutions are designed to produce consistent outcomes across various experimental models and treatment development processes, supporting advancements in cancer research and therapeutic development strategies.

RANKL: A Central Player in Bone and Immune Systems

The receptor activator of nuclear factor κB ligand (RANKL) belongs to the tumor necrosis factor (TNF) superfamily. It is primarily expressed by osteoblasts and activated T-cells and functions as the orchestrator of osteoclast differentiation, activation, and apoptosis through precise regulation of bone remodeling cycles. Beyond skeletal homeostasis, it also has critical involvement in multiple physiological systems - from modulating dendritic cell interactions in immune surveillance to facilitating lactational mammary gland morphogenesis. This molecule's pathological significance extends to multiple oncogenic processes, particularly in promoting osteolytic metastases and cancer-related bone destruction. Such pleiotropic functions position RANKL as a prime molecular target for developing novel therapies against osteoporotic fractures, inflammatory joint destruction, and malignancy-associated skeletal complications.

Alternative Names

Receptor activator of nuclear factor kappa-Β ligand; tumor necrosis factor ligand superfamily member 11; TNFSF11; TNF-related activation-induced cytokine; TRANCE; osteoprotegerin ligand; OPGL; osteoclast differentiation factor; ODF; CD254; OPTB2; hRANKL2; TNLG6B; sOdf.

Background

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Anti-RANKL rAb Products

Creative Biolabs provides an extensive range of high-performance recombinant anti-RANKL antibodies, carefully designed to achieve exceptional specificity and reliable binding capabilities. Our flexible antibody configurations support diverse research needs across immunology investigations, oncology research, and therapeutic discovery programs. Furthermore, we maintain stringent quality assurance processes throughout manufacturing, supported by comprehensive validation testing. Through strategic integration of advanced engineering methodologies with these quality protocols, we produce research reagents demonstrating superior selectivity, stable binding characteristics, and cross-platform reliability—enabling scientists to obtain consistent experimental outcomes in pivotal research initiatives.

Table 1. Featured anti-RANKL recombinant antibody products at Creative Biolabs.

Creative Quality Control

At Creative Biolabs, we are committed to producing exceptional anti-RANKL recombinant antibodies, as evidenced by extensive quality control strategies employed at all stages of manufacturing. This guarantees outstanding selectivity, a high binding affinity, and dependable performance across a range of research applications when combined with rigorous testing and validation.

Customer Reviews

Excellent

Va***l
Mouse Anti-RANKL Recombinant Antibody (clone IK22-5) (FAMAB-1540CQ)

Our laboratory recently purchased Creative Biolabs' anti-RANKL recombinant antibody, and the purchase process was quite smooth. From our initial inquiry to product delivery, CBL's team demonstrated high professionalism in product details. It is particularly worth mentioning that they provided transparent timeline estimates and shipping updates at each stage of the process. The received materials were securely packaged and accompanied by complete certificates of analysis and processing documents.

3/May2024

Excellent

Al***n
Hi-Affi™ Recombinant Rabbit Anti-RANKL Monoclonal Antibody (SI477DS) (MOR-4386)

Using Creative Biolabs' anti-RANKL recombinant antibody was a seamless experience. The product documentation was clear and comprehensive, making initial setup straightforward. We observed consistent and reliable performance in our assays, yielding reproducible results that significantly advanced our bone remodeling studies. The antibody's high specificity minimized off-target effects, simplifying data interpretation and ultimately saving us valuable time and resources. Overall, a positive and efficient user experience.

7/Nov/2024

rAb Production

Creative Biolabs provides a steady global supply of high-quality anti-RANKL recombinant antibodies produced through innovative recombinant technology for research.

Featured Anti-RANKL Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-RANKL recombinant antibody production.

Fig.2 Gram-scale anti-RANKL recombinant antibody production.

rAb Modalities

Creative Biolabs offers customizable and high-quality anti-RANKL recombinant antibodies available in a variety of forms, precisely tailored to meet the specific needs of the international research community.

Fig.3 Full-length anti-RANKL recombinant antibody production and modalities.

RANKL-Targeted Drug Information

Table 2. Public drug targeting RANKL.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Want to learn more or have concerns about our anti-RANKL recombinant antibodies? Feel free to contact us at your convenience.