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    SPI1

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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.
    Protein class

    Human disease related genes, Transcription factors

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Group enriched (Langerhans cells, Macrophages, Hofbauer cells, Kupffer cells, monocytes)

    Immune cell specificity

    Immune cell enhanced (eosinophil)

    Cell line specificity

    Cell line enhanced (HEL, HL-60, HMC-1, NB-4, THP-1, U-698, U-937)

    Interaction

    Binds DNA as a monomer. Interacts with CEBPD and NONO (By similarity). Interacts with RUNX1 and SPIB. Interacts with GFI1; the interaction represses SPI1 transcriptional activity. Interacts with CEBPE (PubMed:26019275).

    Molecular function

    Activator, DNA-binding, RNA-binding

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