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Syne3
Anti-Syne3 Recombinant Antibody Products
- Rabbit Anti-Syne3 Antibody (VS-0722-YJ143) (VS1-YJ143)
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- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: IB, IF, WB, IP
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- Rabbit Anti-SYNE3 Recombinant Antibody (VS13-YC1133) (VS13-YC1133)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.
Enables actin filament binding activity and cytoskeleton-nuclear membrane anchor activity. Involved in cytoskeleton organization; establishment of protein localization to membrane; and regulation of cell shape. Located in nuclear membrane. Part of meiotic nuclear membrane microtubule tethering complex. Biomarker of Huntington's disease.
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Rod photoreceptor cells, Cardiomyocytes, Cone photoreceptor cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (ASC diff, ASC TERT1, Karpas-707, REH)
Interaction
Core component of LINC complexes which are composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain-containing proteins seem to bind each other promiscuously; however, differentially expression of LINC complex constituents can give rise to specific assemblies. Interacts with SUN1 and SUN2; probably forming respective LINC complexes. Interacts with PLEC (via actin-binding domain). Interacts with DST. Interacts with SYNE1 via spectrin repeats. Interacts (via KASH domain) with TOR1A (ATP-bound); the interaction is required for SYNE3 nuclear envelope localization.
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