Rabbit Anti-SYNE3 Recombinant Antibody (VS13-YC1133) (CAT#: VS13-YC1133)
The Rabbit Anti-SYNE3 Recombinant Antibody is specific for human SYNE3. SYNE3 encodes a protein binding actin filaments and anchoring the cytoskeleton to the nuclear membrane, involved in processes like cell shape regulation and cytoskeleton organization. The anti-SYNE3 antibody can be used for Western blot (1/500-1/1000).
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line RH-30
(Immunofluorescent staining of human cell line RH-30 shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/77140/1609_C3_3_selected.jpg
(Immunofluorescent staining of human cell line RH-30 shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/77140/1609_C3_3_selected.jpg
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows distinct nuclear membranous and cytoplasmic positivity in cells in seminiferous ducts.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55227/127589_A_6_6_selected.jpg
(Immunohistochemical staining of human testis shows distinct nuclear membranous and cytoplasmic positivity in cells in seminiferous ducts.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55227/127589_A_6_6_selected.jpg
Figure 3 Colon
(Endothelial cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55227/127589_A_9_3.jpg
(Endothelial cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55227/127589_A_9_3.jpg
Figure 4 Liver
(Hepatocytes
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55227/127589_A_9_4.jpg
(Hepatocytes
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55227/127589_A_9_4.jpg
Figure 5 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55227/127589_A_7_5.jpg
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55227/127589_A_7_5.jpg
Figure 6 Testis
(Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Spermatogonia cells
Staining: High
Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55227/127589_A_6_6.jpg
(Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Spermatogonia cells
Staining: High
Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55227/127589_A_6_6.jpg
Figure 7 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, Karpas-707, REH)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000176438-SYNE3/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000176438-SYNE3/subcellular
Specifications
- Immunogen
- Recombinant human Nesprin3.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human SYNE3
- Species Reactivity
- Human
- Applications
- WB
- Conjugate
- NONE
- Related Disease
- Huntington's disease
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Target
- Alternative Names
- KASH3; NET53; Nesp3; C14orf49; C14orf139; LINC00341; NCRNA00341
- Gene ID
- 161176
- UniProt ID
- Q6ZMZ3
- Long Name
- spectrin repeat containing nuclear envelope family member 3
- Sequence Similarities
- Belongs to the nesprin family.
- Cellular Localization
- Endoplasmic reticulum; Membrane; Nucleus
- Protein Refseq
- NP_001350621.1; NP_001371210.1; NP_001371211.1; NP_001371212.1; NP_001371213.1
- Function
- As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Syne3"
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-1068F | Mouse Anti-Syne3 Recombinant Antibody (clone Nsp-3) | IHC-Fr | Mouse IgG |
| VS1-YJ143 | Rabbit Anti-Syne3 Antibody (VS-0722-YJ143) | IB, IF, WB, IP | Rabbit IgG |
| VS3-FY1798 | Rabbit Anti-SYNE3 Recombinant Antibody (clone R05-1B8) | WB | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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