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TGFBR3
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Hepatic stellate cells, Skeletal myocytes, Leydig cells, Fibroblasts)
Immune cell specificity
Immune cell enhanced (gdT-cell)
Cell line specificity
Cell line enhanced (ASC diff, ASC TERT1, RT4, U-2197)
Interaction
Interacts with DYNLT4.
Molecular function
Receptor
More Types Infomation
Related Signaling Pathways
TGF-β Signaling Pathway
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- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: ELISA
-
- Species Reactivity: Human
- Application: IHC-P, WB
- Recombinant Human Anti-human TGFBR3 Antibody Fab Fragment (MHH-970-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, IP, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, IF, FuncS
- Recombinant Anti-human TGFBR3 Antibody scFv Fragment (MOB-970-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, FuncS
- Recombinant Anti-human TGFBR3 Antibody Fab Fragment (MOB-970-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, ELISA, FuncS
- Recombinant Anti-human TGFBR3 Antibody (MOB-970)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, Neut, FuncS
- Recombinant Human Anti-human TGFBR3 Antibody scFv Fragment (MHH-970-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IF, FuncS
- Mouse Anti-TGFBR3 Recombinant Antibody (clone 10E10) (VS3-QX1121)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC
- Mouse Anti-TGFBR3 Recombinant Antibody (clone 5D11) (VS3-XY1511)
-
- Species Reactivity: Human
- Application: IHC
- Mouse Anti-TGFBR3 Recombinant Antibody (clone 2B7) (VS3-XY1510)
-
- Species Reactivity: Human
- Application: IHC
- Mouse Anti-TGFBR3 Recombinant Antibody (clone 1G11) (VS3-XY1509)
-
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, WB, FC
- Mouse Anti-TGFBR3 Recombinant Antibody (clone 1F8) (VS3-XY1508)
-
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, WB
-
- Type: Mouse IgG2b
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG2b
- Application: WB, ELISA
- Mouse Anti-TGFBR3 Recombinant Antibody (clone 7G11) (VS3-QX1122)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC
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