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TIGIT
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
Predicted location
Membrane
Single cell type specificity
Group enriched (T-cells, NK-cells, dendritic cells)
Immune cell specificity
Immune cell enhanced (T-reg)
Cell line specificity
Cell line enhanced (HDLM-2)
Interaction
Homodimer in cis; binds with high affinity to PVR, forming a heterotetrameric assembly of two TIGIT and two PVR molecules. Binds with lower affinity to NECTIN2 and NECTIN3.
More Types Infomation
- Mouse Anti-TIGIT Recombinant Antibody (clone CBL383) (NEUT-2027CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: Block, CyTOF, FC
- Mouse Anti-TIGIT Recombinant Antibody (clone CBL382) (NEUT-2026CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Block
- Mouse Anti-TIGIT Recombinant Antibody (clone 1G9) (NEUT-2025CQ)
-
- Species Reactivity: Mouse
- Type: Mouse IgG1, κ
- Application: FC, FuncS
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, FC
- Rabbit Anti-Human TIGIT Antibody (MOB-018CQ)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
- Mouse Anti-TIGIT Recombinant Antibody (clone 1B4) (FAMAB-1760CQ)
-
- Species Reactivity: Mouse
- Type: Mouse IgG2a
- Application: Block, ELISA, FC
- Mouse Anti-TIGIT Recombinant Antibody (clone 4D4) (FAMAB-1501CQ)
-
- Species Reactivity: Mouse
- Type: Mouse IgG2a
- Application: Agonist, FC
-
- Species Reactivity: Human
- Type: Humanized Fab
- Application: WB, ELISA, FC, Inhib
-
- Species Reactivity: Human
- Type: Humanized Fab
- Application: WB, ELISA, FC, Inhib
- Rat Anti-TIGIT Recombinant Antibody; Fab Fragment (TAB-661CT-F(E)) (TAB-661CT-F(E))
-
- Species Reactivity: Human
- Type: Rat Fab
- Application: WB, ELISA, FC, Inhib
- Mouse Anti-TIGIT Recombinant Antibody; Fab Fragment (TAB-660CT-F(E)) (TAB-660CT-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB, ELISA, FC, Inhib
- Mouse Anti-TIGIT Recombinant Antibody; Fab Fragment (TAB-659CT-F(E)) (TAB-659CT-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB, ELISA, FC, Inhib
-
- Species Reactivity: Human
- Type: Humanized IgG4
- Application: WB, ELISA, FC, Inhib
-
- Species Reactivity: Human
- Type: Humanized IgG4
- Application: WB, ELISA, FC, Inhib
- Rat Anti-TIGIT Recombinant Antibody (TAB-661CT) (TAB-661CT)
-
- Species Reactivity: Human
- Type: Rat IgG1, κ
- Application: WB, ELISA, FC, Inhib
-
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, FC, Inhib
-
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, FC, Inhib
-
- Species Reactivity: Human
- Type: Humanized scFv
- Application: WB, ELISA, FC, Inhib
- Rat Anti-TIGIT Recombinant Antibody; scFv Fragment (TAB-661CT-S(P)) (TAB-661CT-S(P))
-
- Species Reactivity: Human
- Type: Rat scFv
- Application: WB, ELISA, FC, Inhib
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, ELISA, FC, Inhib
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For Research Use Only. Not For Clinical Use.