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Anti-TIGIT Recombinant Antibody Products

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Anti-TIGIT Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs is proud to offer a superior range of anti-TIGIT recombinant antibody products, meticulously designed to empower global researchers in their cutting-edge immunotherapy endeavors. Our commitment to excellence ensures that these antibodies provide unparalleled specificity and activity, accelerating the development of next-generation cancer treatments and beyond.

TIGIT: A Promising Target for Cancer Immunotherapy

TIGIT (T cell immunoreceptor with Ig and ITIM domains) is a crucial immune checkpoint receptor expressed on various immune cells, including T cells and NK cells. Its interaction with ligands like CD155 and CD112 suppresses anti-tumor immune responses, contributing to immune evasion in the tumor microenvironment. Extensive research highlights TIGIT's significant role in numerous cancers, making it a highly promising target for novel immunotherapeutic strategies aimed at restoring effective anti-tumor immunity and improving patient outcomes.

Alternative Names

T cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; WUCAM; T-cell immunoreceptor with Ig and ITIM domains.

Background

This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses. [provided by RefSeq, Sep 2009]

Predicted location

Membrane

Single cell type specificity

Group enriched (T-cells, NK-cells, dendritic cells)

Immune cell specificity

Immune cell enhanced (T-reg)

Cell line specificity

Cell line enhanced (HDLM-2)

Interaction

Homodimer in cis; binds with high affinity to PVR, forming a heterotetrameric assembly of two TIGIT and two PVR molecules. Binds with lower affinity to NECTIN2 and NECTIN3.

More Types Infomation

Anti-TIGIT rAb Products

Our anti-TIGIT recombinant antibody products stand at the forefront of immunotherapy research, offering exceptional purity, high affinity, and superior batch-to-batch consistency. These antibodies, produced utilizing modern recombinant technology, provide consistent and repeatable results for your crucial tests. Their optimized design provides enhanced binding specificity, minimizing off-target effects and maximizing experimental precision across diverse applications.

Table 1. Featured anti-TIGIT recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
TAB-0279CL Hamster Anti-TIGIT Recombinant Antibody (TAB-0279CL) Mouse Hamster IgG FuncS
HPAB-0669YY Human Anti-TIGIT Recombinant Antibody (HPAB-0669YY) Human Humanized IgG1, κ ELISA, FC, Block, Activ, ADCC
HPAB-0907-YJ Human Anti-TIGIT Recombinant Antibody (HPAB-0907-YJ) Human, Monkey Human IgG1 ELISA, Block
HPAB-0776YY Human Anti-TIGIT Recombinant Antibody (HPAB-0776YY) Human Humanized IgG4 ELISA, Block
HPAB-0780YY Human Anti-TIGIT Recombinant Antibody (HPAB-0780YY) Human Humanized IgG1 WB, ELISA, Block, FC, ADCC

Creative Quality Control

Creative Biolabs' anti-TIGIT recombinant antibodies undergo rigorous, multi-faceted quality control measures, including comprehensive binding assays, functional validation, and purity analysis. This careful method ensures that each product satisfies the highest industry standards for performance and dependability, giving researchers confidence in their experimental results.

Fig.1 SDS-PAGE analysis. (Creative Biolabs Original)Fig.1 SDS-PAGE analysis of anti-TIGIT antibody
(Cat# TAB-0279CL, Creative Biolabs).

Fig.2 HPLC analysis. (Creative Biolabs Original)Fig.2 HPLC analysis of anti-TIGIT antibody
(Cat# TAB-0279CL, Creative Biolabs).

Fig.3 SDS-PAGE analysis. (Creative Biolabs Original)Fig.3 SDS-PAGE analysis of anti-TIGIT antibody
(Cat# HPAB-0669YY, Creative Biolabs).

Fig.4 WB analysis. (Creative Biolabs Original)Fig.4 WB analysis of anti-TIGIT antibody
(Cat# HPAB-0669YY, Creative Biolabs).

Fig.5 ELISA analysis. (Creative Biolabs Original)Fig.5 ELISA analysis of anti-TIGIT antibody
(Cat# HPAB-0669YY, Creative Biolabs).

Customer Reviews

Excellent
Ro***n
Human Anti-TIGIT Recombinant Antibody (HPAB-0669YY) (HPAB-0669YY)
The anti-TIGIT recombinant antibody from Creative Biolabs significantly streamlined our in vitro studies. Its consistent performance and high specificity saved us considerable time and resources, allowing us to generate reliable data much faster. We were particularly impressed with its low background, which made our analysis straightforward and accurate.
13/Oct/2023
Excellent
Da***i
Human Anti-TIGIT Recombinant Antibody (HPAB-0775YY) (HPAB-0775YY)
For our flow cytometry application, Creative Biolabs' anti-TIGIT recombinant antibody proved to be exceptionally versatile. The clear and strong signals we observed were crucial for our cellular analysis, providing high-resolution data. This product has truly elevated the quality and depth of our research findings.
20/May/2024
Excellent
Ve***t
Mouse Anti-TIGIT Recombinant Antibody (HPAB-2959LY) (HPAB-2959LY)
We've incorporated Creative Biolabs' anti-TIGIT antibody into our preclinical models, and the results have been outstanding. The antibody displayed great in vivo effectiveness, which matched exactly with our study aims. Its robust activity and reliable batch consistency make it an indispensable tool for our ongoing therapeutic development.
15/Nov/2024

rAb Production

The production of our anti-TIGIT recombinant antibody products is executed within state-of-the-art mammalian expression systems. This methodology ensures optimal post-translational modifications and preserves intrinsic biological activity. This advanced production platform facilitates large-scale manufacturing while upholding rigorous quality standards, thereby providing researchers with a consistent and ample supply of high-performance antibodies essential for their projects.

Featured Anti-TIGIT Recombinant Antibody Production PlatformsFig.6 Milligram-scale. (Creative Biolabs Original)
Fig.6 Milligram-scale anti-TIGIT recombinant antibody production.

Fig.7 Gram-scale. (Creative Biolabs Original)Fig.7 Gram-scale anti-TIGIT recombinant antibody production.

rAb Modalities

We offer anti-TIGIT recombinant antibodies in various modalities, catering to diverse research and therapeutic development needs.

Fig.8 TIGIT antibody production and modalities. (Creative Biolabs Original)Fig.8 Full-length anti-TIGIT recombinant antibody production and modalities.

TIGIT-Targeted Drug Information

Table 2. Public drug targeting TIGIT.

Company Research phase Classification Condition
AstraZeneca (Originator) Phase III Bispecific Antibodies
Cancer Immunotherapy
Cancer, bile duct
Cancer, gastroesophageal junction (adenocarcinoma)
Cancer, hepatobiliary
Cancer, liver
Cancer, lung (non-small cell) (NSCLC)
Cancer, lung (non-small cell) (NSCLC), metastatic
Cancer, stomach
BeiGene (Originator)
Novartis
Phase III Cancer Immunotherapy
Humanized Monoclonal Antibodies
Cancer, cervix
Cancer, lung (non-small cell) (NSCLC)
Cancer, solid tumor
Cholangiocarcinoma, intrahepatic
Esophageal carcinoma (squamous cell)
GlaxoSmithKline (GSK)
GSK
iTeos Therapeutics (Originator)
Phase III Cancer Immunotherapy
Human Monoclonal Antibodies
Cancer
Cancer, head and neck (squamous cell carcinoma)
Cancer, lung (non-small cell) (NSCLC)
Cancer, lung (non-small cell) (NSCLC), metastatic
Cancer, solid tumor
Melanoma
Multiple myeloma
Arcus Biosciences (Originator)
Gilead
Taiho
Phase III Cancer Immunotherapy
Humanized Monoclonal Antibodies
Cancer
Cancer, bladder
Cancer, breast
Cancer, endometrium
Cancer, gastroesophageal junction (adenocarcinoma)
Cancer, kidney
Cancer, lung (non-small cell) (NSCLC)
Cancer, lung (non-small cell) (NSCLC), metastatic
Cancer, ovary
Cancer, solid tumor
Cancer, stomach (adenocarcinoma)
Digestive-gastrointestinal cancer
Esophageal adenocarcinoma
Glioblastoma
Melanoma
Merck & Co (Originator)
Merck & Co. (Merck & Co)
Phase III Cancer Immunotherapy
Chimeric Monoclonal Antibodies
Cancer, lung (non-small cell) (NSCLC)
Cancer, lung (non-small cell) (NSCLC), metastatic
Cancer, solid tumor
Melanoma
Chugai Pharmaceutical
Genentech (Originator)
Roche (Originator)
Phase III Cancer Immunotherapy
Human Monoclonal Antibodies
Cancer
Cancer, bladder (urothelial carcinoma)
Cancer, cervix
Cancer, gastroesophageal junction (adenocarcinoma)
Cancer, head and neck (squamous cell carcinoma)
Cancer, liver (hepatocellular carcinoma)
Cancer, lung (non-small cell) (NSCLC)
Cancer, lung (small cell) (SCLC)
Cancer, lung (small cell) (SCLC) (extensive)
Cancer, pancreas (ductal adenocarcinoma)
Cancer, solid tumor
Cancer, stomach
Esophageal carcinoma (squamous cell)
Lymphoma, B-cell
Melanoma
Multiple myeloma
Merck KGaA (Originator) Phase II Cancer Immunotherapy
Human Monoclonal Antibodies
Cancer, bladder (urothelial carcinoma)
Cancer, solid tumor
Suzhou Zelgen Biosciences (Originator) Phase I/II Bispecific Antibodies
Cancer Immunotherapy
Humanized Monoclonal Antibodies
Cancer, cervix
Cancer, liver (hepatocellular carcinoma)
Cancer, solid tumor
Neuroendocrine cancer
Huaota Biopharm (Originator) Phase I/II Bispecific Antibodies
Cancer Immunotherapy
Cancer, lung (non-small cell) (NSCLC)
Cancer, solid tumor
Biotheus (Originator) Phase I/II Bispecific Antibody Fusions
Cancer Immunotherapy
Fusion Proteins
Polypeptides, from 41 AA
Single-Domain Antibodies
Cancer, solid tumor
Shanghai Henlius Biotech (Originator) Phase I/II Bispecific Antibodies
Cancer Immunotherapy
Humanized Monoclonal Antibodies
Cancer, bladder (urothelial carcinoma)
Cancer, gastrointestinal
Cancer, head and neck (squamous cell carcinoma)
Cancer, lung (non-small cell) (NSCLC)
Cancer, solid tumor

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Creative Biolabs is dedicated to accelerating your research with our premium anti-TIGIT recombinant antibody products. We invite you to explore our comprehensive portfolio and discover how our expertise can support your scientific breakthroughs. For detailed product information, technical support, or to discuss your specific project requirements, please do not hesitate to reach out to us.

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