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VAV2

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For Research Use Only. Not For Clinical Use.


Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
Protein class

Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Hepatocytes, Inhibitory neurons)

Immune cell specificity

Immune cell enhanced (memory B-cell)

Cell line specificity

Low cell line specificity

Interaction

Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with SSX2IP (By similarity). Interacts with NEK3 and PRLR and this interaction is prolactin-dependent.

Molecular function

Guanine-nucleotide releasing factor

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