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VEGFR2

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For Research Use Only. Not For Clinical Use.


Background

VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) is a key receptor tyrosine kinase that plays a crucial role in angiogenesis (the formation of new blood vessels) and endothelial cell function. It binds to Vascular Endothelial Growth Factor (VEGF), which then triggers signaling pathways that regulate blood vessel formation, endothelial cell survival, proliferation, and migration. Because of its role in tumor growth, VEGFR2 is a significant target for cancer therapies, specifically VEGFR2 tyrosine kinase inhibitors, which block its signaling to inhibit tumor angiogenesis.
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