10-FnIII scaffold protein anti-Human The Src-homology 2 (SH2) domain-containing phosphatase 2 (SHP2) (CAT#: SFN-L025)

The tenth fibronectin type III domain (10Fn3) that bound the Src-homology 2 (SH2) domain-containing phosphatase 2 (SHP2) was isolated from the library using Phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities for the Src-homology 2 (SH2) domain-containing phosphatase 2 (SHP2) as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.