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    Recombinant Anti-mouse PTEN Intrabody [(D-Arg)9] (CAT#: IAB-B021(A))

    Recombinant anti-PTEN intrabody linked to (D-Arg)9 works within cells and directs against PTEN in T cells, expressed in CHO cells. The intrabody can modulate the expression and/or activity of PTEN in T cells, regulatory T cells, and CD4 T cells.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line MCF7
    Figure 1 IF staining of human cell line MCF7
    (Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/31335/if_selected.jpg
    Figure 2 IHC staining of human testis
    Figure 2 IHC staining of human testis
    (Immunohistochemical staining of human testis shows cytoplasmic positivity in cells in seminiferous ducts.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/31335/134179_A_5_6_selected.jpg
    Normal Tissue
    Figure 3 Cerebral cortex
    Figure 3 Cerebral cortex
    (Neuronal cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Neuropil
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4076/12125_B_8_5.jpg
    Figure 4 Lymph node
    Figure 4 Lymph node
    (Germinal center cells
    Staining: Low
    Intensity: Weak
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous nuclear
    Non-germinal center cells
    Staining: Low
    Intensity: Weak
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4076/12125_A_8_8.jpg
    RNA Expression
    Figure 5 RNA cell line category: Low cell line specificity
    Figure 5 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000171862-PTEN/subcellular

    Specifications

    • Immunogen
    • mouse phosphatase and tensin homolog
    • Host Species
    • human
    • Type
    • scFv-(D-Arg)9
    • Cell Penetrating Peptide
    • (D-Arg)9
      It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
    • Species Reactivity
    • mouse
    • Applications
    • Antibody assay: Protein fragment complementation; Western blot; Functional studies

    Product Property

    • Purity
    • Purity>95% by SDS-PAGE
    • Storage
    • Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.

    Target

    • Alternative Names
    • PTEN; phosphatase and tensin homolog; TEP1; MMAC1; AI463227; 2310035O07Rik; A130070J02Rik; B430203M17Rik; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; mitochondrial PTENalpha; mutated in multiple ad

    Related Resources

    • Related Diseases
    • Related Signaling Pathways

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "PTEN"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    Intrabody Products Rabbit Monoclonal Antibody Products IgG Antibody Products Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
    CAT Product Name Application Type
    IAB-B021(G) Recombinant Anti-mouse PTEN Intrabody [+36 GFP] FACS, ELISA, IF, FuncS scFv-(+36GFP)
    IAB-B021(T) Recombinant Anti-mouse PTEN Intrabody [Tat] FACS, ICC, FuncS scFv-Tat

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