Recombinant Anti-mouse PTEN Intrabody [+36 GFP]
CAT#: IAB-B021(G)
Recombinant anti-PTEN intrabody in fusion with +36GFP works within cells to bind PTEN in T cells, expressed in CHO cells. The intrabody can modulate the expression and/or activity of PTEN in T cells, regulatory T cells, and CD4 T cells.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31335/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows cytoplasmic positivity in cells in seminiferous ducts.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31335/134179_A_5_6_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4076/12125_B_8_5.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Non-germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4076/12125_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000171862-PTEN/subcellular
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Specifications
- Immunogen
- mouse phosphatase and tensin homolog
- Host Species
- human
- Type
- scFv-(+36GFP)
- Cell Penetrating Peptide
- +36 GFP
GFP with a theoretical net charge of +36 (+36 GFP) penetrated several different mammalian cell lines at very low (nanomolar) concentrations. Cationic peptides and proteins have been observed to penetrate cells, and both natural and synthetic cell-penetrating peptides are widely used as delivery vehicles. However, whereas a covalent link between the cell-penetrating peptide and its cargo is typically required.
- Species Reactivity
- mouse
- Applications
- Used for immunoassay techniques such as: Fluorescence-activated cell sorting; Enzyme-linked Immunosorbent Assay; Immunofluorescence; Functional studies
Product Property
- Purity
- >95% as determined by analysis by RP-HPLC
- Storage
- 4 °C, -20°C if preferred
Target
- Alternative Names
- PTEN; phosphatase and tensin homolog; TEP1; MMAC1; AI463227; 2310035O07Rik; A130070J02Rik; B430203M17Rik; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; mitochondrial PTENalpha; mutated in multiple ad
- Gene ID
- 19211
- UniProt ID
- O08586
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Related Diseases
Endometrial Cancer
Related Signaling Pathways
mTOR Signaling Pathway
PI3K-Akt Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "PTEN"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B021(A) | Recombinant Anti-mouse PTEN Intrabody [(D-Arg)9] | PCA, WB, FuncS | scFv-(D-Arg)9 |
| IAB-B021(T) | Recombinant Anti-mouse PTEN Intrabody [Tat] | FACS, ICC, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2915 | Hi-Affi™ Recombinant Rabbit Anti-PTEN Monoclonal Antibody (DS2915AB) | ICC, IHC-P, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX925 | Mouse Anti-PTEN Recombinant Antibody (clone 4G4-4H9-1E10) | IHC | Mouse IgG1 |
| VS3-QX926 | Mouse Anti-PTEN Recombinant Antibody (clone 7H2-6G9-6H5) | IHC | Mouse IgG1 |
| VS3-QX927 | Mouse Anti-PTEN Recombinant Antibody (clone 1B8) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-CJ1061 | Mouse Anti-PTEN Recombinant Antibody (VS3-CJ1061) | WB | Mouse IgG1, κ |
| VS3-CJ1062 | Rabbit Anti-PTEN Recombinant Antibody (VS3-CJ1062) | WB, ICC, IF, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY183 | CytoStream™ Mouse Anti-PTEN Recombinant Antibody (VS-0225-XY183) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1816 | Anti-PTEN Immunohistochemistry Kit | IHC | |
| VS-0525-XY5823 | Anti-Mouse PTEN Immunohistochemistry Kit | IHC | |
| VS-0525-XY5822 | Anti-Human PTEN Immunohistochemistry Kit | IHC | |
| VS-0525-XY5824 | Anti-Rat PTEN Immunohistochemistry Kit | IHC |
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