PTEN

Antibody-like Scaffold Protein Products AbPlus Recombinant Antibody Products Functional Antibody Products Formats

Anti-PTEN Recombinant Antibody Products

Mouse Anti-PTEN Recombinant Antibody (clone 27C11) (MOB-1640z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IF
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Mouse Anti-PTEN Recombinant Antibody (clone 4D8) (VS3-XY1314)
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP, IF
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Rabbit Anti-PTEN (pS380) Recombinant Antibody (clone R08-7W6) (VS3-WK2147)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF
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Rabbit Anti-Phospho-PTEN (S380) Recombinant Antibody (clone 4D10) (ZG-0527U)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB
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Mouse Anti-PTEN Recombinant Antibody (clone 4G4-4H9-1E10) (VS3-QX925)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC
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Mouse Anti-PTEN Recombinant Antibody (clone 7H2-6G9-6H5) (VS3-QX926)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC
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Mouse Anti-PTEN Recombinant Antibody (clone 1B8) (VS3-QX927)
- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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Mouse Anti-PTEN Recombinant Antibody (VS3-CJ1061) (VS3-CJ1061)
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1, κ
- Application: WB
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Rabbit Anti-PTEN Recombinant Antibody (VS3-CJ1062) (VS3-CJ1062)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC
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Recombinant Mouse Anti-Human PTEN Antibody (clone 7I3.2) (MOB-0338MZ)
- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC
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Recombinant Rabbit Anti-PTEN Monoclonal Antibody (CBACN-466) (MRO-1293-CN)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
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Recombinant Rabbit Anti-PTEN (phosphorylated Ser380) Monoclonal Antibody (CBACN-651) (MRO-2365-CN)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF
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Mouse Anti-PTEN Recombinant Antibody (clone 2C10) (MOB-0231F)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: IHC-P, IF
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Mouse Anti-PTEN Recombinant Antibody (clone 9E8) (MOB-0232F)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: IHC-P, IF
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10-FnIII scaffold protein anti-Human The Src-homology 2 (SH2) domain-containing phosphatase 2 (SHP2) (SFN-L025)
- Scaffold Name: 10-FnIII
- Target: The Src-homology 2 (SH2) domain-containing phosphatase 2 (SHP2)
- Species Reactivity: Human
- Derivation: Phage display
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PDZ domain scaffold protein anti-Human PTEN (SPD-L152)
- Scaffold Name: PDZ domain
- Target: PTEN
- Species Reactivity: Human
- Derivation: Phage display
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Hi-Affi™ Recombinant Rabbit Anti-PTEN Monoclonal Antibody (DS2915AB) (MOR-2915)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ICC, IHC-P, IP, WB
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Anti-PTEN (clone W24V123) Recombinant Antibody Coupled Liposome (VS-1024-FY125) (VS-1024-FY125)
- Antibody Host: Mouse
- Antibody Reactivity: Human
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Anti-PTEN (clone W24V222) Recombinant Antibody Coupled Liposome (VS-1024-FY219) (VS-1024-FY219)
- Antibody Host: Mouse
- Antibody Reactivity: Human
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CytoStream™ Mouse Anti-PTEN Recombinant Antibody (VS-0225-XY183) (VS-0225-XY183)
- Species Reactivity: Human, Mouse, Rat, Dog
- Type: Mouse IgG1, kappa
- Application: FC
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Recombinant Anti-mouse PTEN Intrabody [(D-Arg)₉] (IAB-B021(A))
- Species Reactivity: mouse
- Type: scFv-(D-Arg)₉
- Application: PCA, WB, FuncS
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Recombinant Anti-mouse PTEN Intrabody [+36 GFP] (IAB-B021(G))
- Species Reactivity: mouse
- Type: scFv-(+36GFP)
- Application: FACS, ELISA, IF, FuncS
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Recombinant Anti-mouse PTEN Intrabody [Tat] (IAB-B021(T))
- Species Reactivity: mouse
- Type: scFv-Tat
- Application: FACS, ICC, FuncS
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For Research Use Only. Not For Clinical Use.

PTEN (Phosphatase and Tensin Homolog) is a tumor suppressor gene that encodes a lipid phosphatase involved in regulating the PI3K/AKT signaling pathway. PTEN negatively regulates this pathway, which is essential for cell growth, survival, and metabolism. Loss of PTEN function leads to uncontrolled cell growth and is commonly associated with various cancers, including glioblastoma and prostate cancer.

Protein class

Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Immune cell enhanced (neutrophil)

Cell line specificity

Low cell line specificity

Interaction

Monomer. The unphosphorylated form interacts with the second PDZ domain of MAGI2 and with DLG1 and MAST2 in vitro (PubMed:10646847, 10760291, 11707428). Interacts with MAGI2, MAGI3, MAST1 and MAST3, but neither with MAST4 nor with DLG5; interaction with MAGI2 increases protein stability (PubMed:10748157, 15951562). Interacts with NEDD4 (PubMed:17218260). Interacts with NDFIP1 and NDFIP2; in the presence of NEDD4 or ITCH, this interaction promotes PTEN ubiquitination (PubMed:25801959, 20534535). Interacts (via C2 domain) with FRK (PubMed:19345329). Interacts with USP7; the interaction is direct (PubMed:18716620). Interacts with ROCK1 (By similarity). Interacts with XIAP/BIRC4 (PubMed:19473982). Interacts with STK11; the interaction phosphorylates PTEN (PubMed:15987703). Interacts with PPP1R16B (PubMed:25007873). Interacts with NOP53; regulates PTEN phosphorylation and increases its stability (PubMed:15355975).

Molecular function

Hydrolase, Protein phosphatase

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Related Diseases

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