Anti-CD72 (clone 10D6.8.1)-MCC-DM1 ADC
CAT#: ADC-178LZY
This ADC product is composed of an anti-CD72 antibody (clone 10D681 ) conjugated via MCC linker to DM1 (10D681-MCC-DM1). It has demonstrated a response in non-Hodgkin's lymphoma treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/44658/1373_H2_4_selected.jpg
Normal Tissue
Figure 2 Spleen
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/ihc_selected.jpg
Normal Tissue
Figure 3 Bone marrow
Hematopoietic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/6524_B_5_4.jpg
Normal Tissue
Figure 4 High expression in lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/6524_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Daudi, Karpas-707, REH, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000137101-CD72
❮
❯
Specifications
- Antibody Overview
- Mouse Anti-CD72 IgG1,10D6.8.1
- Clone
- 10D681
- Antibody Isotype
- IgG1
- Linker
- MCC (Maleimidomethyl cyclohexane-1-carboxylate)
- Linker Class/Description
- Class: Noncleavable linker
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
- Drug
- DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
Target
- Introduction
- CD72 (Cluster of Differentiation 72), also known in murine biology as Lyb-2, is a protein active in the immune system of animals. It consists of two identical halves, each of about 39-43 kD, and is a C-type lectin. Its primarily locus of expression is B-cells, where it appears to mediate aspects of B-cell-T-cell interaction. It is a ligand for CD5.
- Alternative Names
- CD72; CD72 molecule; LYB2; CD72b; B-cell differentiation antigen CD72; lyb-2; CD72 antigen;
- Gene ID
- 971
- UniProt ID
- P21854
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for ADC-178LZY. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 10D681"
- CAT
- Product Name
See other products for "CD72"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1916z | Mouse Anti-CD72 Recombinant Antibody (clone 24B5) | WB, FC, IHC, IP | Mouse IgG2a |
| HPAB-0062CQ | Human Anti-CD72 Recombinant Antibody (clone sc02-004) | IHC | Human IgG1, κ |
| HPAB-0063CQ | Human Anti-CD72 Recombinant Antibody (clone sc02-025) | IHC | Human IgG1, λ |
| VS7-HM633 | Mouse Anti-CD72 Recombinant Antibody (clone 2F3B8) | FCM | Mouse IgG2b |
| VS7-HM634 | Mouse Anti-CD72 Recombinant Antibody (clone 4G4B1) | FCM | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G083P | Anti-CD72 immunotoxin J3-109 (IgG)-PAP | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0578 | Hi-Affi™ Rabbit Anti-CD72 Recombinant Antibody (clone DS578AB) | ICC, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0062CQ-S(P) | Human Anti-CD72 Recombinant Antibody (clone sc02-004); scFv Fragment | IHC | Human scFv |
| HPAB-0063CQ-S(P) | Human Anti-CD72 Recombinant Antibody (clone sc02-025); scFv Fragment | IHC | Human scFv |
| HPAB-2053-FY-S(P) | Human Anti-CD72 Recombinant Antibody (clone II-2); scFv Fragment | FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0062CQ-F(E) | Human Anti-CD72 Recombinant Antibody (clone sc02-004); Fab Fragment | IHC | Human Fab |
| HPAB-0063CQ-F(E) | Human Anti-CD72 Recombinant Antibody (clone sc02-025); Fab fragment | IHC | Human Fab |
| HPAB-2053-FY-F(E) | Human Anti-CD72 Recombinant Antibody (clone II-2); Fab Fragment | FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC506 | Recombinant Anti-CD72 Vesicular Antibody, EV Displayed (VS-0425-YC506) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1216 | Anti-CD72 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
-2.png)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA, SPR, Inhib, FuncS
-YJ5.png)
Application: WB, ELISA, FC, IHC, IP
Application: ELISA, FC, WB, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: Neut, ELISA, WB, SPR, IF, EM
Application: ELISA, FC, WB, Inhib, IHC
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
