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Anti-CD72 (clone 10D6.8.1)-mc-vc-PABC-MMAE ADC (CAT#: ADC-179LZY)

This ADC product is composed of an anti-CD72 antibody (clone 10D681 ) conjugated via mc-vc-PABC linker to MMAE (10D681-mc-vc-PABC-MMAE). It has demonstrated a response in non-Hodgkin's lymphoma treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line SH-SY5Y
Figure 1 IF staining of human cell line SH-SY5Y
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/44658/1373_H2_4_selected.jpg
Normal Tissue
Figure 2 Spleen
Figure 2 Spleen
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/ihc_selected.jpg
Figure 3 Bone marrow
Figure 3 Bone marrow
(Hematopoietic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/6524_B_5_4.jpg
Figure 4 High expression in lymph node
Figure 4 High expression in lymph node
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/6524_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Daudi, Karpas-707, REH, U-698)
Figure 5 RNA cell line category: Cell line enhanced (Daudi, Karpas-707, REH, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000137101-CD72

Specifications

  • Antibody Overview
  • Mouse Anti-CD72 IgG1,10D6.8.1
  • Clone
  • 10D681
  • Antibody Isotype
  • IgG1
  • Linker
  • mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
  • Linker Class/Description
  • Class: Enzymatically cleavable linker-Peptide linker
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAE (monomethyl auristatin E)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • CD72 (Cluster of Differentiation 72), also known in murine biology as Lyb-2, is a protein active in the immune system of animals. It consists of two identical halves, each of about 39-43 kD, and is a C-type lectin. Its primarily locus of expression is B-cells, where it appears to mediate aspects of B-cell-T-cell interaction. It is a ligand for CD5.
  • Alternative Names
  • CD72; CD72 molecule; LYB2; CD72b; B-cell differentiation antigen CD72; lyb-2; CD72 antigen;

Downloads

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Immunotoxin

CAT Product Name Application Type
AGTO-G083P Anti-CD72 immunotoxin J3-109 (IgG)-PAP Cytotoxicity assay, Function study

Recombinant Antibody

CAT Product Name Application Type
MOB-0273MC Human Anti-CD72 Recombinant Antibody (clone YC015) ELISA, WB, FuncS
MOB-0274MC Human Anti-CD72 Recombinant Antibody (clone YC016); scFv Fragment ELISA, WB, FuncS Human scFv
HPAB-0062CQ Human Anti-CD72 Recombinant Antibody (clone sc02-004) IHC Human IgG1, κ
HPAB-0063CQ Human Anti-CD72 Recombinant Antibody (clone sc02-025) IHC Human IgG1, λ
FAMAB-1080CQ Human Anti-CD72 Recombinant Antibody (clone BU40) WB, FC, Apop Human IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0578 Hi-Affi™ Rabbit Anti-CD72 Recombinant Antibody (clone DS578AB) ICC, WB Rabbit IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0062CQ-S(P) Human Anti-CD72 Recombinant Antibody (clone sc02-004); scFv Fragment IHC Human scFv
HPAB-0063CQ-S(P) Human Anti-CD72 Recombinant Antibody (clone sc02-025); scFv Fragment IHC Human scFv
HPAB-2053-FY-S(P) Human Anti-CD72 Recombinant Antibody (clone II-2); scFv Fragment FC Human scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0062CQ-F(E) Human Anti-CD72 Recombinant Antibody (clone sc02-004); Fab Fragment IHC Human Fab
HPAB-0063CQ-F(E) Human Anti-CD72 Recombinant Antibody (clone sc02-025); Fab fragment IHC Human Fab
HPAB-2053-FY-F(E) Human Anti-CD72 Recombinant Antibody (clone II-2); Fab Fragment FC Human Fab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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