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Anti-PMEL17 (31D1.6.7)-mc-vc-MMAE ADC (CAT#: ADC-150LCT)

This ADC product is composed of an anti-PMEL17 antibody (clone 31D1.6.7) conjuagated via a mc-vc linker to MMAE (31D1.6.7-MMAE). It has demonstrated a response in Melanoma treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SK-MEL-30
Figure 1 IF staining of human cell line SK-MEL-30
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to endoplasmic reticulum & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/1898_C6_19_cr5ba8a6f6e250d_selected.jpg
Normal Tissue
Figure 2 Kidney
Figure 2 Kidney
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_A_7_5.jpg
Figure 3 Testis
Figure 3 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_A_4_6.jpg
Figure 4 Skin
Figure 4 Skin
(Melanocytes
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_B_7_1.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (SK-MEL-30)
Figure 5 RNA cell line category: Cell line enriched (SK-MEL-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185664-PMEL

Specifications

  • Clone
  • 31D1.6.7
  • Linker
  • mc-VC (maleimidocaproyl-valine-citrulline)
  • Linker Class/Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAE (Monomethyl auristatin E)
  • Drug Class/Description
  • Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
  • Alternative Names
  • P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E

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Recombinant Antibody

CAT Product Name Application Type
MOB-1280z Mouse Anti-PMEL Recombinant Antibody (clone 21C9) ICC, IF, IHC Mouse IgG1
ZG-0592F Mouse Anti-PMEL Recombinant Antibody (clone HMB45) IHC-P Mouse IgG1
VS3-CJ934 Mouse Anti-PMEL Recombinant Antibody (clone PT1593) IHC-P Mouse IgG2b, κ
VS3-CJ935 Mouse Anti-PMEL Recombinant Antibody (clone ABT-PMEL) IHC-P Mouse IgG2b, κ
VS-0723-WK139 Human Anti-PMEL Recombinant Antibody (VS-0723-WK139) FC Chimeric (rabbit/human) IgG1

Immunotoxin

CAT Product Name Application Type
AGTO-G051E Anti-PMEL immunotoxin (Fab)-PE Cytotoxicity assay, Function study

Mouse Antibody

CAT Product Name Application Type
TAB-1047CL-F(E) Anti-Human PMEL Recombinant Antibody Fab Fragment (A3F) IHC, WB, FC
TAB-1048CL-F(E) Anti-Human PMEL Recombinant Antibody Fab Fragment (G11B) IHC, WB, FC
TAB-1049CL-F(E) Anti-Human PMEL Recombinant Antibody Fab Fragment (J7E) IHC, WB, FC
TAB-1050CL-F(E) Mouse Anti-PMEL Recombinant Antibody; Fab Fragment (TAB-1050CL-F(E)) FC Mouse Fab
TAB-1051CL-F(E) Mouse Anti-PMEL Recombinant Antibody; Fab Fragment (TAB-1051CL-F(E)) FC Mouse Fab

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC210 H-2Db/Human Mouse gp100 (EGSRNQDWL) MHC Tetramer FCM
MHC-LC211 H-2Db Mouse gp100 (EGSRNQDWL) MHC Tetramer FCM
MHC-LC774 A*0201/Human gp100 (ITDQVPFSV) MHC Tetramer FCM
MHC-LC775 A*0201/Human gp100 (IMDQVPFSV) MHC Tetramer FCM
MHC-LC776 A*0201/Human gp100 (VLYRYGSFSV) MHC Tetramer FCM

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2761 Hi-Affi™ Recombinant Rabbit Anti-PMEL Monoclonal Antibody (DS2761AB) IHC-P IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0046-LSX-S(P) Mouse Anti-PMEL Recombinant Antibody; scFv Fragment (HPAB-0046-LSX-S(P)) ELISA, WB, FC Mouse scFv
HPAB-0047-LSX-S(P) Mouse Anti-PMEL Recombinant Antibody; scFv Fragment (HPAB-0047-LSX-S(P)) ELISA, WB, FC Mouse scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0046-LSX-F(E) Mouse Anti-PMEL Recombinant Antibody; Fab Fragment (HPAB-0046-LSX-F(E)) ELISA, WB, FC Mouse Fab
HPAB-0047-LSX-F(E) Human Anti-PMEL Recombinant Antibody; Fab Fragment (HPAB-0047-LSX-F(E)) ELISA, WB, FC Chimeric Fab

MHC Tetramer for Virology

CAT Product Name Application Type
MHC-YF186 H-2Db/HPV16 E7 (RAHYNIVTF) MHC Monomer MHC Multimer
MHC-YF214 B*15:01/EBV EBNA4 (GQGGSPTAM) MHC Monomer MHC Multimer
MHC-YF225 A*02:01/HPV16 E7 (YMLDLQPET) MHC Monomer MHC Multimer
MHC-YF295 A*02:01/HPV E7 (YMLDLQPETT) MHC Monomer MHC Multimer

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