Anti-PMEL17 (31D1.6.7)-mc-vc-MMAE ADC
CAT#: ADC-150LCT
This ADC product is composed of an anti-PMEL17 antibody (clone 31D1.6.7) conjuagated via a mc-vc linker to MMAE (31D1.6.7-MMAE). It has demonstrated a response in Melanoma treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to endoplasmic reticulum & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/1898_C6_19_cr5ba8a6f6e250d_selected.jpg
Normal Tissue
Figure 2 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_A_7_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_A_4_6.jpg
Normal Tissue
Figure 4 Skin
Melanocytes
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_B_7_1.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185664-PMEL
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Specifications
- Clone
- 31D1.6.7
- Linker
- mc-VC (maleimidocaproyl-valine-citrulline)
- Linker Class/Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
- Alternative Names
- P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E
- Gene ID
- 6490
- UniProt ID
- P40967
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COA
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| TAB-1047CL-F(E) | Anti-Human PMEL Recombinant Antibody Fab Fragment (A3F) | IHC, WB, FC | |
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| TAB-1050CL-F(E) | Mouse Anti-PMEL Recombinant Antibody; Fab Fragment (TAB-1050CL-F(E)) | FC | Mouse Fab |
| TAB-1051CL-F(E) | Mouse Anti-PMEL Recombinant Antibody; Fab Fragment (TAB-1051CL-F(E)) | FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2761 | Hi-Affi™ Recombinant Rabbit Anti-PMEL Monoclonal Antibody (DS2761AB) | IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0046-LSX-S(P) | Mouse Anti-PMEL Recombinant Antibody; scFv Fragment (HPAB-0046-LSX-S(P)) | ELISA, WB, FC | Mouse scFv |
| HPAB-0047-LSX-S(P) | Mouse Anti-PMEL Recombinant Antibody; scFv Fragment (HPAB-0047-LSX-S(P)) | ELISA, WB, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0046-LSX-F(E) | Mouse Anti-PMEL Recombinant Antibody; Fab Fragment (HPAB-0046-LSX-F(E)) | ELISA, WB, FC | Mouse Fab |
| HPAB-0047-LSX-F(E) | Human Anti-PMEL Recombinant Antibody; Fab Fragment (HPAB-0047-LSX-F(E)) | ELISA, WB, FC | Chimeric Fab |
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| CAT | Product Name | Application | Type |
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