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    APC-A*02:01/Human PSCA (AILALLPAL) MHC Tetramer (CAT#: MHC-LC022)

    This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of PSCA-derived peptide of AILALLPAL sequence covering 105-133 and A*02:01 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

    Specific Inquiry
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    Custom Production

    MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

    Peptide Sequence *:
    Allele Requested *:
    Antigen Species:
    Antigen Molecule:
    Sequence Position:
    Form Requested *:
    Conjugation *:
    Size *:
    Comments:

    Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line HeLa
    Figure 1 IF staining of human cell line HeLa
    (Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/30783/1550_B1_8_selected.jpg
    Figure 2 IHC staining of human kidney
    Figure 2 IHC staining of human kidney
    (Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in subset of renal tubules.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/ihc_selected.jpg
    Normal Tissue
    Figure 3 Stomach
    Figure 3 Stomach
    (Glandular cells
    Staining: Low
    Intensity: Moderate
    Quantity: <25%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_6_1.jpg
    Figure 4 Colon
    Figure 4 Colon
    (Glandular cells
    Staining: Low
    Intensity: Moderate
    Quantity: <25%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_9_3.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in tubules
    Staining: Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_7_5.jpg
    RNA Expression
    Figure 6 RNA cell line category: Cell line enhanced (CAPAN-2, HeLa, OE19, RT4)
    Figure 6 RNA cell line category: Cell line enhanced (CAPAN-2, HeLa, OE19, RT4)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167653-PSCA/subcellular

    Specifications

    • Allele
    • A*02:01
    • Class
    • Class I
    • MHC Species
    • Human
    • Antigen
    • PSCA
    • Antigen Species
    • Human
    • Peptide
    • AILALLPAL
    • Range
    • 105-133
    • Conjugate
    • APC
    • Application
    • FCM

    Target

    • Antigen Introduction
    • This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants.
    • Alternative Names
    • PSCA; prostate stem cell antigen; PRO232

    Downloads

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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