Recombinant Anti-PSCA Vesicular Antibody, EV Displayed (VS-0425-YC192) (CAT#: VS-0425-YC192)
The Recombinant Anti-PSCA Vesicular Antibody, EV Displayed (VS-0425-YC192) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PSCA-expressed cells or tissues. The PSCA is a glycosylphosphatidylinositol-anchored glycoprotein expressed in tissues like the prostate and bladder, upregulated in many prostate cancers. A polymorphism in this gene is associated with gastric and bladder cancers.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30783/1550_B1_8_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30783/1550_B1_8_selected.jpg
Figure 2 IHC staining of human kidney
(Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in subset of renal tubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/ihc_selected.jpg
(Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in subset of renal tubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/ihc_selected.jpg
Figure 3 Stomach
(Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_6_1.jpg
(Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_6_1.jpg
Figure 4 Colon
(Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_9_3.jpg
(Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_9_3.jpg
Figure 5 Kidney
(Cells in tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_7_5.jpg
(Cells in tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_7_5.jpg
Figure 6 RNA cell line category: Cell line enhanced (CAPAN-2, HeLa, OE19, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167653-PSCA/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167653-PSCA/subcellular
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- PSCA
- Host Animal
- Human
- Antibody Isotype
- IgG2
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Prostate stem cell antigen
- Cellular Localization
- Plasma membrane
- Introduction
- This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers.
- Alternative Names
- lncPSCA
- Gene ID
- 8000
- UniProt ID
- O43653
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1981z | Mouse Anti-PSCA Recombinant Antibody (clone 24F5) | WB, FC, IF | Mouse IgG1, κ |
| MOB-1641CT | Recombinant Mouse anti-Human PSCA Monoclonal antibody (EML781) | IHC-P, WB | |
| HPAB-0074-CN | Mouse Anti-PSCA Recombinant Antibody (HPAB-0074-CN) | FC | Mouse IgG1, κ |
| VS7-0425-WR699 | Mouse Anti-PSCA Recombinant Antibody (clone 5H5A7) | ICC, FC | Mouse IgG2a |
| VS7-0425-WR700 | Mouse Anti-PSCA Recombinant Antibody (clone 3F4E4) | FC | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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