Recombinant Anti-PSCA Vesicular Antibody, EV Displayed (VS-0425-YC192)
CAT#: VS-0425-YC192
The Recombinant Anti-PSCA Vesicular Antibody, EV Displayed (VS-0425-YC192) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PSCA-expressed cells or tissues. The PSCA is a glycosylphosphatidylinositol-anchored glycoprotein expressed in tissues like the prostate and bladder, upregulated in many prostate cancers. A polymorphism in this gene is associated with gastric and bladder cancers.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30783/1550_B1_8_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human kidney
Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in subset of renal tubules.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/ihc_selected.jpg
Normal Tissue
Figure 3 Stomach
Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_6_1.jpg
Normal Tissue
Figure 4 Colon
Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_7_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (CAPAN-2, HeLa, OE19, RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167653-PSCA/subcellular
❮
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- PSCA
- Host Animal
- Human
- Antibody Isotype
- IgG2
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Prostate stem cell antigen
- Cellular Localization
- Plasma membrane
- Introduction
- This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers.
- Alternative Names
- lncPSCA
- Gene ID
- 8000
- UniProt ID
- O43653
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "PSCA"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1981z | Mouse Anti-PSCA Recombinant Antibody (clone 24F5) | WB, FC, IF | Mouse IgG1, κ |
| MOB-1641CT | Recombinant Mouse anti-Human PSCA Monoclonal antibody (EML781) | IHC-P, WB | |
| HPAB-0074-CN | Mouse Anti-PSCA Recombinant Antibody (HPAB-0074-CN) | FC | Mouse IgG1, κ |
| HPAB-1309WJ | Mouse Anti-PSCA Recombinant Antibody (clone 6B8) | ELISA, WB | Mouse IgG |
| VS-0723-WK291 | Rabbit Anti-PSCA Recombinant Antibody (VS-0723-WK291) | ELISA, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-729CL | Human Anti-PSCA Recombinant Antibody (TAB-729CL) | ELISA | Human IgG |
| TAB-259CT | Anti-Human PSCA Recombinant Antibody (10C5) | IHC, FC | Human antibody |
| TAB-260CT | Anti-Human PSCA Recombinant Antibody (6E4) | IHC, FC | Human antibody |
| TAB-261CT | Anti-Human PSCA Recombinant Antibody (6D1) | IHC, FC | Human antibody |
| TAB-259CT-S(P) | Anti-Human PSCA Recombinant Antibody scFv Fragment (10C5) | IHC, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-256CT | Anti-Human PSCA Recombinant Antibody (6B8) | IHC, FC | |
| TAB-257CT | Anti-Human PSCA Recombinant Antibody (1D7) | IHC, FC | |
| TAB-258CT | Anti-Human PSCA Recombinant Antibody (2B3) | IHC, FC | |
| TAB-256CT-S(P) | Anti-Human PSCA Recombinant Antibody scFv Fragment (6B8) | IHC, FC | |
| TAB-257CT-S(P) | Anti-Human PSCA Recombinant Antibody scFv Fragment (1D7) | IHC, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-262CT | Humanized Anti-PSCA Recombinant Antibody (TAB-262CT) | FuncS | Humanized antibody |
| TAB-262CT-S(P) | Humanized Anti-PSCA Recombinant Antibody; scFv Fragment (TAB-262CT-S(P)) | ELISA, FC | Humanized scFv |
| TAB-262CT-F(E) | Humanized Anti-PSCA Recombinant Antibody; Fab Fragment (TAB-262CT-F(E)) | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC021 | PE-A*02:01/Human PSCA (AILALLPAL) MHC Tetramer | FCM | |
| MHC-LC022 | APC-A*02:01/Human PSCA (AILALLPAL) MHC Tetramer | FCM | |
| MHC-LC023 | BV421-A*02:01/Human PSCA (AILALLPAL) MHC Tetramer | FCM | |
| MHC-CN1165 | PE-A*02:01/Human PSCA (QLGEQCWTV) MHC Tetramer | FCM, IHC | |
| MHC-CN1166 | APC-A*02:01/Human PSCA (QLGEQCWTV) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0074-CN-S(P) | Mouse Anti-PSCA Recombinant Antibody; scFv Fragment (HPAB-0074-CN-S(P)) | FC | Mouse scFv |
| HPAB-0287CQ-S(P) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 8D11); scFv Fragment | FC, IHC | Mouse scFv |
| HPAB-0288CQ-S(P) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 6F8); scFv Fragment | FC, IHC | Mouse scFv |
| HPAB-1309WJ-S(P) | Mouse Anti-PSCA Recombinant Antibody (clone 6B8); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-1900-FY-F(E) | Human Anti-PSCA Recombinant Antibody; Fab Fragment (HPAB-1900-FY-F(E)) | FC, Inhib, WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0074-CN-F(E) | Mouse Anti-PSCA Recombinant Antibody; Fab Fragment (HPAB-0074-CN-F(E)) | FC | Mouse Fab |
| HPAB-0286CQ-F(E) | Human Anti-PSCA Recombinant Antibody (clone mAb 5F2); Fab Fragment | FC, IHC | Chimeric (mouse/human) Fab |
| HPAB-0287CQ-F(E) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 8D11); Fab Fragment | FC, IHC | Mouse Fab |
| HPAB-0288CQ-F(E) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 6F8); Fab Fragment | FC, IHC | Mouse Fab |
| HPAB-1309WJ-F(E) | Mouse Anti-PSCA Recombinant Antibody (clone 6B8); Fab Fragment | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY152 | Mouse Anti-PSCA (clone 6B8) scFv-Fc Chimera | ELISA, Cyt, FC | Mouse IgG1, scFv-Fc |
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