Mouse Anti-PSCA (clone 6B8) scFv-Fc Chimera
CAT#: VS-0325-FY152
An anti-PSCA scFv-Fc antibody is a fusion protein that targets prostate stem cell antigen (PSCA). It's made up of two peptides that form a homodimer. Each peptide contains the variable domains of an anti-PSCA antibody, as well as a truncated hinge and fragment crystallizable (Fc) region.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30783/1550_B1_8_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human kidney
Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in subset of renal tubules.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/ihc_selected.jpg
Normal Tissue
Figure 3 Stomach
Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_6_1.jpg
Normal Tissue
Figure 4 Colon
Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_7_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (CAPAN-2, HeLa, OE19, RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167653-PSCA/subcellular
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- High specificity towards PSCA.
- Species Reactivity
- Human
- Clone
- 6B8
- Applications
- ELISA, Cytotoxicity, Flow Cytometry
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Flow Cytometry: 10 μg/mL
Target
- Alternative Names
- PSCA; Prostate Stem Cell Antigen
- Long Name
- Prostate Stem Cell Antigen
- Cellular Localization
- Cell membrane; Lipid-anchor, GPI-anchor
- Post Translation Modifications
- N-glycosylated.
Glycosylation at Asn31
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_005663.2
- Function
- May be involved in the regulation of cell proliferation.
Has a cell-proliferation inhibition activity in vitro. PSCA_HUMAN,O43653
May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
See other products for "Clone 6B8"
- CAT
- Product Name
See other products for "PSCA"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-729CL | Human Anti-PSCA Recombinant Antibody (TAB-729CL) | ELISA | Human IgG |
| TAB-259CT | Anti-Human PSCA Recombinant Antibody (10C5) | IHC, FC | Human antibody |
| TAB-260CT | Anti-Human PSCA Recombinant Antibody (6E4) | IHC, FC | Human antibody |
| TAB-261CT | Anti-Human PSCA Recombinant Antibody (6D1) | IHC, FC | Human antibody |
| TAB-259CT-F(E) | Anti-Human PSCA Recombinant Antibody Fab Fragment (10C5) | IHC, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-256CT | Anti-Human PSCA Recombinant Antibody (6B8) | IHC, FC | |
| TAB-257CT | Anti-Human PSCA Recombinant Antibody (1D7) | IHC, FC | |
| TAB-258CT | Anti-Human PSCA Recombinant Antibody (2B3) | IHC, FC | |
| TAB-256CT-F(E) | Anti-Human PSCA Recombinant Antibody Fab Fragment (6B8) | IHC, FC | |
| TAB-257CT-F(E) | Anti-Human PSCA Recombinant Antibody Fab Fragment (1D7) | IHC, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-262CT | Humanized Anti-PSCA Recombinant Antibody (TAB-262CT) | FuncS | Humanized antibody |
| TAB-262CT-S(P) | Humanized Anti-PSCA Recombinant Antibody; scFv Fragment (TAB-262CT-S(P)) | ELISA, FC | Humanized scFv |
| TAB-262CT-F(E) | Humanized Anti-PSCA Recombinant Antibody; Fab Fragment (TAB-262CT-F(E)) | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1641CT | Recombinant Mouse anti-Human PSCA Monoclonal antibody (EML781) | IHC-P, WB | |
| HPAB-0074-CN | Mouse Anti-PSCA Recombinant Antibody (HPAB-0074-CN) | FC | Mouse IgG1, κ |
| HPAB-1309WJ | Mouse Anti-PSCA Recombinant Antibody (clone 6B8) | ELISA, WB | Mouse IgG |
| HPAB-1900-FY | Human Anti-PSCA Recombinant Antibody (HPAB-1900-FY) | FC, Inhib, WB, ELISA | Human IgG1 |
| VS-0723-WK291 | Rabbit Anti-PSCA Recombinant Antibody (VS-0723-WK291) | ELISA, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC021 | PE-A*02:01/Human PSCA (AILALLPAL) MHC Tetramer | FCM | |
| MHC-LC022 | APC-A*02:01/Human PSCA (AILALLPAL) MHC Tetramer | FCM | |
| MHC-LC023 | BV421-A*02:01/Human PSCA (AILALLPAL) MHC Tetramer | FCM | |
| MHC-CN1165 | PE-A*02:01/Human PSCA (QLGEQCWTV) MHC Tetramer | FCM, IHC | |
| MHC-CN1166 | APC-A*02:01/Human PSCA (QLGEQCWTV) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0074-CN-S(P) | Mouse Anti-PSCA Recombinant Antibody; scFv Fragment (HPAB-0074-CN-S(P)) | FC | Mouse scFv |
| HPAB-0287CQ-S(P) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 8D11); scFv Fragment | FC, IHC | Mouse scFv |
| HPAB-0288CQ-S(P) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 6F8); scFv Fragment | FC, IHC | Mouse scFv |
| HPAB-1309WJ-S(P) | Mouse Anti-PSCA Recombinant Antibody (clone 6B8); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-1900-FY-F(E) | Human Anti-PSCA Recombinant Antibody; Fab Fragment (HPAB-1900-FY-F(E)) | FC, Inhib, WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0074-CN-F(E) | Mouse Anti-PSCA Recombinant Antibody; Fab Fragment (HPAB-0074-CN-F(E)) | FC | Mouse Fab |
| HPAB-0286CQ-F(E) | Human Anti-PSCA Recombinant Antibody (clone mAb 5F2); Fab Fragment | FC, IHC | Chimeric (mouse/human) Fab |
| HPAB-0287CQ-F(E) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 8D11); Fab Fragment | FC, IHC | Mouse Fab |
| HPAB-0288CQ-F(E) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 6F8); Fab Fragment | FC, IHC | Mouse Fab |
| HPAB-1900-FY-S(P) | Human Anti-PSCA Recombinant Antibody; scFv Fragment (HPAB-1900-FY-S(P)) | FC, Inhib, WB, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC192 | Recombinant Anti-PSCA Vesicular Antibody, EV Displayed (VS-0425-YC192) | ELISA, FC, Cell-uptake |
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