Mouse Anti-PSCA (clone 6B8) scFv-Fc Chimera (CAT#: VS-0325-FY152)
An anti-PSCA scFv-Fc antibody is a fusion protein that targets prostate stem cell antigen (PSCA). It's made up of two peptides that form a homodimer. Each peptide contains the variable domains of an anti-PSCA antibody, as well as a truncated hinge and fragment crystallizable (Fc) region.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30783/1550_B1_8_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30783/1550_B1_8_selected.jpg
Figure 2 IHC staining of human kidney
(Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in subset of renal tubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/ihc_selected.jpg
(Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in subset of renal tubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/ihc_selected.jpg
Figure 3 Stomach
(Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_6_1.jpg
(Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_6_1.jpg
Figure 4 Colon
(Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_9_3.jpg
(Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_9_3.jpg
Figure 5 Kidney
(Cells in tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_7_5.jpg
(Cells in tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_7_5.jpg
Figure 6 RNA cell line category: Cell line enhanced (CAPAN-2, HeLa, OE19, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167653-PSCA/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167653-PSCA/subcellular
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- High specificity towards PSCA.
- Species Reactivity
- Human
- Clone
- 6B8
- Applications
- ELISA, Cytotoxicity, Flow Cytometry
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Flow Cytometry: 10 μg/mL
Target
- Alternative Names
- PSCA; Prostate Stem Cell Antigen
- Long Name
- Prostate Stem Cell Antigen
- Cellular Localization
- Cell membrane; Lipid-anchor, GPI-anchor
- Post Translation Modifications
- N-glycosylated.
Glycosylation at Asn31
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_005663.2
- Function
- May be involved in the regulation of cell proliferation.
Has a cell-proliferation inhibition activity in vitro. PSCA_HUMAN,O43653
May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.
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Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1981z | Mouse Anti-PSCA Recombinant Antibody (clone 24F5) | WB, FC, IF | Mouse IgG1, κ |
| HPAB-0074-CN | Mouse Anti-PSCA Recombinant Antibody (HPAB-0074-CN) | FC | Mouse IgG1, κ |
| HPAB-1309WJ | Mouse Anti-PSCA Recombinant Antibody (clone 6B8) | ELISA, WB | Mouse IgG |
| HPAB-1900-FY | Human Anti-PSCA Recombinant Antibody (HPAB-1900-FY) | FC, Inhib, WB, ELISA | Human IgG1 |
| VS-0723-WK291 | Rabbit Anti-PSCA Recombinant Antibody (VS-0723-WK291) | ELISA, FC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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