APC-A1/Human PCNA (ITEDMGHLKY) MHC Tetramer

Name: APC-A1/Human PCNA (ITEDMGHLKY) MHC Tetramer
SKU: MHC-LC3417
Rating: 5 (1 reviews)

CAT#: MHC-LC3417

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human PCNA of peptide ITEDMGHLKY and A1 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/148/if_selected.jpg

Normal Tissue Figure 2 Colon

Glandular cells
Staining:

High

Intensity: Strong
Quantity: 75%-25%
Location: Nuclear

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30523/64162_A_9_3.jpg

Normal Tissue Figure 3 Testis

Leydig cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%

Preleptotene spermatocytes
Staining:

Medium

Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30523/64162_A_6_6.jpg

Normal Tissue Figure 4 Bone marrow

Hematopoietic cells
Staining:

High

Intensity: Strong
Quantity: 75%-25%
Location: Nuclear

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30523/64162_B_5_4.jpg

Normal Tissue Figure 5 Lymph node

Germinal center cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Nuclear
Non-germinal center cells
Staining:

Medium

Intensity: Strong
Quantity: <25%
Location: Nuclear

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30523/64162_A_7_8.jpg

RNA Expression Figure 6 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000132646-PCNA

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Specifications

Allele
A1

Class
Class I

MHC Species
Human

Antigen
PCNA

Antigen Species
Human

Peptide
ITEDMGHLKY

Conjugate
APC

Application
FCM

Target

Antigen Introduction
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.

Alternative Names
PCNA; proliferating cell nuclear antigen; ATLD2

Gene ID
5111

UniProt ID
Q9BXX2

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Datasheet

Datasheet - MHC-LC3417.pdf

MSDS

MSDS - MHC-LC3417.pdf

COA

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