APC-DRB*01:01/Human PMEL (WNRQLYPEWTEAQRLD) MHC Tetramer

CAT#: MHC-LC1803

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of PMEL-derived peptide of WNRQLYPEWTEAQRLD covering 44-59 and DRB*01:01 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.

Gene Expression
Figure 1 IF staining of human cell line SK-MEL-30 Figure 2 Kidney Figure 3 Testis Figure 4 Skin Figure 5 RNA cell line category: Cell line enriched (SK-MEL-30)

Specifications

  • Allele
  • DRB*01:01
  • Class
  • Class II
  • MHC Species
  • Human
  • Antigen
  • gp100
  • Antigen Species
  • Human
  • Peptide
  • WNRQLYPEWTEAQRLD
  • Range
  • 44-59
  • Conjugate
  • APC

Target

  • Antigen Introduction
  • This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
  • Alternative Names
  • PMEL; premelanosome protein; P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E
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