Anti-αvβ3 Integrin Recombinant Antibody (Etaracizumab/Etaratuzumab/Medi-522) (CAT#: TAB-705)
Recombinant humanized (from mouse) antibody expressed in CHO binding to human αVβ3 integrin. Etaracizumab is a humanized monoclonal antibody which is being investigated for the treatment of metastatic melanoma, prostate cancer, ovarian cancer and various other types of cancer.
Specific Inquiry
ELISA
Figure 1 Serum MEDI-522 concentrations.
Serum concentrations of MEDI-522 were determined by ELISA at multiple time points for each patient over the first 8 weeks. Points, means of MEDI-522 serum concentrations per dose cohort at each time point collected; bars, SD.
McNeel, D. G., Eickhoff, J., Lee, F. T., King, D. M., Alberti, D., Thomas, J. P.,... & Zhang, J. (2005). Phase I trial of a monoclonal antibody specific for αvβ3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion. Clinical Cancer Research, 11(21), 7851-7860.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG2 - kappa
- Species Reactivity
- Human
- Applications
- FC, IP, ELISA, Neut, FuncS, IF, IHC
- Trade name
- abegrin
- CAS
- 892553-42-3
- Generic Name
- etaracizumab/etaratuzumab/MEDI-522
- UNII
- 41W9MFI160
- MW
- 144.3 kDa
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Applications
- Application Notes
- The αVβ3 integrin antibody has been reported in applications of FC, IP, ELISA, Neut, FuncS, IF, IHC.
Target
- Alternative Names
- etaracizumab/etaratuzumab/MEDI-522;abegrin;892553-42-3;Etaratuzumab;MEDI-522;Abegrin;αVβ3
Related Resources
Please refer to Etaracizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Etaracizumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "αVβ3 integrin"
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-705 | Afuco™ Anti-αVβ3 Integrin ADCC Recombinant Antibody (Etaracizumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1305WJ | Human Anti-αvβ3 Integrin Recombinant Antibody (clone LM609) | ELISA | Humanized IgG |
| HPAB-A1325-YJ | Mouse Anti-αvβ3 Integrin Recombinant Antibody (clone D12) | ELISA, Inhib, FC | Mouse IgG1 |
| HPAB-A1326-YJ | Human Anti-αvβ3 Integrin Recombinant Antibody (clone chD12) | ELISA, Inhib, FC | Chimeric (mouse/human) IgG1 |
| HPAB-A1327-YJ | Human Anti-αvβ3 Integrin Recombinant Antibody (clone huD12) | ELISA, Inhib, FC | Humanized IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1305WJ-S(P) | Human Anti-αvβ3 Integrin Recombinant Antibody (clone LM609); scFv Fragment | ELISA | Humanized scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1305WJ-F(E) | Human Anti-αvβ3 Integrin Recombinant Antibody (clone LM609); Fab Fragment | ELISA | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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