Human Anti-ABCB11 Recombinant Antibody (clone Malimo); Fab Fragment (CAT#: HPAB-0191-CN-F(E))
Antibody Malimo is an isolated monoclonal antibody that specifically binds to an extracellular epitope on the N-terminal half of BSEP and modulates BSEP function. Antibody Malimo recognizes an epitope present on the C-terminal half of BSEP.
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Custom Production
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/if_selected.jpg
Figure 2 High expression in liver
(Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/49515_A_9_4.jpg
(Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/49515_A_9_4.jpg
Figure 3 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/49515_A_4_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/49515_A_4_6.jpg
Figure 4 RNA cell line category: Cell line enhanced (NB-4, RT4, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000073734-ABCB11
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000073734-ABCB11
Specifications
- Host Species
- Human
- Type
- Human Fab
- Specificity
- Human ABCB11
- Species Reactivity
- Human, Rat
- Clone
- Malimo
- Applications
- WB, FC, IF
- Related Disease
- Cancer such as hepatocellular carcinoma and hepatoblastoma
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11; Progressive Familial Intrahepatic Cholestasis 2; ATP-Binding Cassette Sub-Family B Member 11; BSEP; ABC Member 16, MDR/TAP Subfamily; Bile Salt Export Pump; Sister P-Glycoprotein; MDR/TAP Subfamily; ABC Member 16; EC 3.6.3.44; EC 3.6.3; PFIC-2; ABC16; BRIC2; PFIC2; PGY4; SPGP
- Gene ID
- 8647
- UniProt ID
- O95342
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2146z | Mouse Anti-ABCB11 Recombinant Antibody (clone 38B10) | WB, ELISA, IF, IHC, IP | Mouse IgG2a, κ |
| HPAB-0190-CN | Human Anti-ABCB11 Recombinant Antibody (clone Batist) | WB, FC, IF | Human IgG1 |
| HPAB-0191-CN | Human Anti-ABCB11 Recombinant Antibody (clone Malimo) | WB, FC, IF | Human IgG1 |
| HPAB-0192-CN | Human Anti-ABCB11 Recombinant Antibody (clone Tweed) | WB, FC, IF | Human IgG1 |
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For Research Use Only. Not For Clinical Use.
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