Anti-Human AQP4 Recombinant Antibody
CAT#: TAB-053CL
Recombinant Human monoclonal antibody expressed in CHO binding to Human AQP4. Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO, a study on antibody titre. Neuromyelitis optica (NMO) is an autoimmune inflammatory disorder of the central nervous system. In most NMO patients, autoantibodiess to the water channel protein Aquaporin 4 (AQP4) are present at high levels and are thought to drive pathology by mediating complement-dependent destruction of astrocytes.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14784/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cell junctions.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5079/if_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Glial cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14784/141530_B_7_5.jpg
Normal Tissue
Figure 4 Lung
Alveolar cells type I
Staining: High
Intensity: Strong
Quantity: 75%-25%
Alveolar cells type II
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14784/141530_A_3_4.jpg
Normal Tissue
Figure 5 Kidney
Distal tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14784/141530_A_8_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (AF22, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171885-AQP4
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Related Disease
- Neuromyelitis optica
Product Property
- Purity
- >95% by HPLC
- Storage
- Store at -20°C for long-term storage. Store at 4°C for up to one month. Avoid freeze/thaw cycles.
Target
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Relevant For NMO Research
This recombinant human monoclonal antibody is an excellent tool for studying Neuromyelitis optica. It binds specifically to human AQP4. We used it to model autoantibody binding to astrocytes in vitro. The high purity (HPLC>95%) ensures that our results are due to the antibody itself.
Stable And Specific
We have been using this antibody for months, and it remains stable at -20°C. It binds to the water channel protein AQP4 with high specificity. It is a crucial reagent for our experiments investigating the pathogenesis of autoimmune inflammatory disorders of the CNS.
Q&As
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What is the primary application of this antibody?
A: This Anti-AQP4 Recombinant Antibody is a Human monoclonal antibody used primarily for research into Neuromyelitis optica (NMO). It binds human AQP4 and is useful for studying autoantibody-mediated pathology.
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What is the purity of this product?
A: The antibody has a purity of greater than 95% as determined by HPLC. It is expressed in CHO cells and provided in a preservative-free format.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "AQP4"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1110z | Mouse Anti-AQP4 Recombinant Antibody (clone 28H5) | WB, IP, IF, IHC, FC | Mouse IgG3 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0977CLV | Anti-Human AQP4 Recombinant Antibody (D15107) | ELISA, FuncS, WB, IF, FC | Chimeric antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0672MZ | Mouse Anti-AQP4 Recombinant Antibody (clone 4E3) | ELISA, IHC-Fr, IHC-P, IP, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0223 | Hi-Affi™ Rabbit Anti-AQP4 Recombinant Antibody (clone DS223AB) | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| MOB-086CQ | Mouse Anti-AQP4 Recombinant Antibody (clone CBLS-192) | ELISA, IHC-Fr, IHC-P, WB, IHC-FoFr | Mouse IgG3, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0035J | Mouse Anti-AQP4 Recombinant Antibody (clone 4H1) | WB, IHC-P, IF, ICC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-CJ1042 | Mouse Anti-AQP4 Recombinant Antibody (VS3-CJ1042) | WB, ICC, IF, IHC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC282 | Recombinant Anti-AQP4 Vesicular Antibody, EV Displayed (VS-0425-YC282) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY479 | Anti-AQP4 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY480 | Anti-Mouse AQP4 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY481 | Anti-Rat AQP4 Immunohistochemistry Kit | IHC |
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