anti-ASTL immunotoxin D-8 (Fab)-Sap
CAT#: AGTO-L044S
This immunotoxin was achieved by conjugating/fusing the Anti-ASTL Fab to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to kidney cancer and pancreatic cancer cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of kidney cancer and pancreatic cancer.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15620/36614_A_8_2_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15620/36614_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15620/36614_A_9_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15620/36614_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15620/36614_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15620/36614_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15620/36614_A_7_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000188886-ASTL
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Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- D-8
- Molecule Class
- L kappa; Fab-Sap
- Toxin Description
- Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Kidney cancer and pancreatic cancer
Target
- Alternative Names
- SAS1B; ASTL; astacin-like metallo-endopeptidase; M12 family; Kidney cancer; pancreatic cancer; saporin; saporin-6; saporin-S6; SAP
- Gene ID
- 431705
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone D-8"
- CAT
- Product Name
See other products for "ASTL"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0630-YC | Mouse Anti-ASTL Recombinant Antibody (clone 7H2) | WB, IP | Mouse IgG1, κ |
| HPAB-M0631-YC | Mouse Anti-ASTL Recombinant Antibody (clone 6C1) | WB, IP | Mouse IgG1, κ |
| HPAB-M0632-YC | Mouse Anti-ASTL Recombinant Antibody (clone 3F2) | WB, IF | Mouse IgG |
| HPAB-M0633-YC | Mouse Anti-ASTL Recombinant Antibody (clone 6B1) | IHC, IF, WB | Mouse IgG |
| HPAB-M0634-YC | Rabbit Anti-ASTL Recombinant Antibody (clone 1H2/1K2) | WB, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0630-YC-S(P) | Mouse Anti-ASTL Recombinant Antibody (clone 7H2); scFv Fragment | WB, IP | Mouse scFv |
| HPAB-3128LY-S(P) | Human Anti-ASTL Recombinant Antibody (clone SB1); scfv Fragment | ELISA, WB, IF | Human scfv |
| HPAB-3129LY-S(P) | Human Anti-ASTL Recombinant Antibody (clone SB2); scfv Fragment | ELISA, WB, IF | Human scfv |
| HPAB-3130LY-S(P) | Human Anti-ASTL Recombinant Antibody (clone SB4); scfv Fragment | ELISA, WB, IF | Human scfv |
| HPAB-3131LY-S(P) | Human Anti-ASTL Recombinant Antibody (clone SB5); scfv Fragment | ELISA, WB, IF | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0630-YC-F(E) | Mouse Anti-ASTL Recombinant Antibody (clone 7H2); Fab Fragment | WB, IP | Mouse Fab |
| HPAB-M0631-YC-F(E) | Mouse Anti-ASTL Recombinant Antibody (clone 6C1); Fab Fragment | WB, IP | Mouse Fab |
| HPAB-M0632-YC-F(E) | Mouse Anti-ASTL Recombinant Antibody (clone 3F2); Fab Fragment | WB, IF | Mouse Fab |
| HPAB-M0633-YC-F(E) | Mouse Anti-ASTL Recombinant Antibody (clone 6B1); Fab Fragment | WB, IF | Mouse Fab |
| HPAB-M0634-YC-F(E) | Rabbit Anti-ASTL Recombinant Antibody (clone 1H2/1K2); Fab Fragment | WB, FC | Rabbit Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY21 | AbPlus™ Anti-ASTL Magnetic Beads (7H2) | IP, Protein Purification |
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