Mouse Anti-ASTL Recombinant Antibody (clone 6B1) (CAT#: HPAB-M0633-YC)
mAb 6B1 is recombinant monoclonal antibody to SAS1B. Clone 6B1 recognized amino acids 55-289 of human SAS1B.
Specific Inquiry
IHC
Figure 1 SAS1B was expressed in a majority of pancreatic cancers and was not detected in normal pancreas ductal epithelium by IHC.
TMAs were stained for the expression of SAS1B with 6B1 mAb. SAS1B was not detected in normal pancreatic ductal epithelium and most pancreatic intraepithelial lesions. Many ductal carcinomas showed cytoplasmic SAS1B staining.
Knapp, K. A., Pires, E. S., Adair, S. J., Mandal, A., Mills, A. M., Olson, W. C., ... & Herr, J. C. (2018). Evaluation of SAS1B as a target for antibody-drug conjugate therapy in the treatment of pancreatic cancer. Oncotarget, 9(10), 8972.
IF
Figure 2 SAS1B localized to the cytoplasm and to the cell surface in pancreatic cancer cell lines.
Fixed and permeabilized indirect immunofluorescence (IIF) using anti-SAS1B mAb, SB2 showed SAS1B localized to the cytoplasm of three pancreatic cancer cell lines (mPanc96, 366, 608) compared to normal keratinocytes.
Knapp, K. A., Pires, E. S., Adair, S. J., Mandal, A., Mills, A. M., Olson, W. C., ... & Herr, J. C. (2018). Evaluation of SAS1B as a target for antibody-drug conjugate therapy in the treatment of pancreatic cancer. Oncotarget, 9(10), 8972.
Specifications
- Immunogen
- SAS1B SVA amino acids 55-289
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human ASTL
- Species Reactivity
- Human
- Clone
- 6B1
- Applications
- IHC, IF, WB
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The ASTL antibody has been reported in applications of Immunohistochemistry, Immunofluorescence, Western Blot.
Target
- Alternative Names
- Astacin Like Metalloendopeptidase; Astacin-Like Metallo-Endopeptidase (M12 Family); Sperm Acrosomal SLLP1 Binding; Oocyte Astacin; Ovastacin; Astacin-Like Metalloendopeptidase (M12 Family); Astacin-Like Metalloendopeptidase; EC 3.4.-.-; SAS1B;
- Gene ID
- 431705
- UniProt ID
- Q6HA08
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Immunotoxin
Recombinant Antibody
scFv Fragment Antibody
Fab Fragment Antibody
Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L044S | anti-ASTL immunotoxin D-8 (Fab)-Sap | Cytotoxicity assay, Functional assay |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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