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    For Research Use Only. Not For Clinical Use.


    Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding.
    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (T-cells, Macrophages, Glandular and luminal cells)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Cell line enhanced (RT4)

    Interaction

    Interacts (via N-terminal domain) with SPACA3; the interaction occurs during fertilization.

    Molecular function

    Hydrolase, Metalloprotease, Protease

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