Anti-CASP3 Intrabody [(D-Arg)9] (IAB-B002(A))
Recombinant anti-CASP3 intrabody linked to (D-Arg)9 works within cells and specifically binds to pro-apoptotic protein CASP3, expressed in CHO cells. These intrabodies are useful drugs on their own as well as a means for identifying small compound drugs for degenerative diseases involving oxidative-stress-induced apoptosis.
Specifications
- Immunogen
- human caspase 3, apoptosis-related cysteine peptidase
- Host
- llama
- Type
- vhh-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Antibody assay: Western blot; Immunocytochemistry; Functional studies
Target
- Alternative Names
- CASP3; caspase 3, apoptosis-related cysteine peptidase; CPP32; SCA-1; CPP32B; caspase-3; CASP-3; CPP-32
- Entrez Gene ID
- 836
- UniProt ID
- P42574
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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